Difference between revisions of "Intratumoural lymphocytic response in colorectal carcinoma"

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[[Image:Tumour-infiltrating lymphocytes - 2 -- very high mag.jpg|thumb|right|Intratumoural lymphocytic response in colorectal carcinoma, as may be seen in [[microsatellite instability]]. [[H&E stain]]. (WC)]]
[[Image:Tumour-infiltrating lymphocytes - 2 -- very high mag.jpg|thumb|right|Intratumoural lymphocytic response in colorectal carcinoma, as may be seen in [[Microsatellite instability in colorectal cancer|microsatellite instability]]. [[H&E stain]]. (WC)]]
This article deals with '''intratumoural lymphocytic response in colorectal carcinoma'''. It is usually referred to as '''intratumoural lymphocytic response'''.
This article deals with the '''intratumoural lymphocytic response in colorectal carcinoma'''. It is usually referred to as '''intratumoural lymphocytic response'''.


It is also known as '''tumour-infiltrating lymphocytes''', abbreviated '''TILs'''.
It is also known as '''tumour-infiltrating lymphocytes''', abbreviated '''TILs'''.
A general discussion about TILs is in the ''[[tumour-infiltrating lymphocytes]]'' article.


==General==
==General==
*Finding is suggestive of [[microsatellite instability]].<ref name=pmid21114775>{{Cite journal  | last1 = Iacopetta | first1 = B. | last2 = Grieu | first2 = F. | last3 = Amanuel | first3 = B. | title = Microsatellite instability in colorectal cancer. | journal = Asia Pac J Clin Oncol | volume = 6 | issue = 4 | pages = 260-9 | month = Dec | year = 2010 | doi = 10.1111/j.1743-7563.2010.01335.x | PMID = 21114775 }}</ref>
*Finding is suggestive of [[Microsatellite instability in colorectal cancer|microsatellite instability]].<ref name=pmid21114775>{{Cite journal  | last1 = Iacopetta | first1 = B. | last2 = Grieu | first2 = F. | last3 = Amanuel | first3 = B. | title = Microsatellite instability in colorectal cancer. | journal = Asia Pac J Clin Oncol | volume = 6 | issue = 4 | pages = 260-9 | month = Dec | year = 2010 | doi = 10.1111/j.1743-7563.2010.01335.x | PMID = 21114775 }}</ref>
**May be seen in the context of [[Lynch syndrome]].
**May be seen in the context of [[Lynch syndrome]].


Latest revision as of 14:33, 25 May 2016

Intratumoural lymphocytic response in colorectal carcinoma, as may be seen in microsatellite instability. H&E stain. (WC)

This article deals with the intratumoural lymphocytic response in colorectal carcinoma. It is usually referred to as intratumoural lymphocytic response.

It is also known as tumour-infiltrating lymphocytes, abbreviated TILs.

A general discussion about TILs is in the tumour-infiltrating lymphocytes article.

General

Microscopic

Features:

  • >10 lymphocytes/0.94 mm2.[2] †
    • Lymphocytes must be between the tumour cells.[2][3] ††
      • Lymphocytes elsewhere, e.g. in the peritumoural stroma, do not count.
      • Typically, the lymphocytes have a halo around them.

Notes:

  • † Greenson et al. says >2 lymphocytes/HPF, where 5 HPF are sampled with the 40x objective. Since the sample area given by Greenson et al. is 0.94 mm2, the field diameter is ~ 0.4892 mm. This field diameter corresponds to a 20 mm eye piece (0.4892 mm * 40x = 19.57 mm).
    • Many microscopes in use today have a field diameter (at 40x) of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm2.
  • †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".[4]

Images

  • TILs - high mag. (WC)

  • TILS - very high mag. (WC)

  • TILs - high mag.

  • TILs - very high mag.

  • TILs - extremely high mag.

www:

See also

References

  1. ↑ Iacopetta, B.; Grieu, F.; Amanuel, B. (Dec 2010). "Microsatellite instability in colorectal cancer.". Asia Pac J Clin Oncol 6 (4): 260-9. doi:10.1111/j.1743-7563.2010.01335.x. PMID 21114775.
  2. ↑ 2.0 2.1 Greenson, JK.; Bonner, JD.; Ben-Yzhak, O.; Cohen, HI.; Miselevich, I.; Resnick, MB.; Trougouboff, P.; Tomsho, LD. et al. (May 2003). "Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability.". Am J Surg Pathol 27 (5): 563-70. PMID 12717242.
  3. ↑ 3.0 3.1 Garg, K.; Soslow, RA. (Aug 2009). "Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma.". J Clin Pathol 62 (8): 679-84. doi:10.1136/jcp.2009.064949. PMID 19638537.
  4. ↑ Ropponen, KM.; Eskelinen, MJ.; Lipponen, PK.; Alhava, E.; Kosma, VM. (Jul 1997). "Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer.". J Pathol 182 (3): 318-24. doi:10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6. PMID 9349235.
  5. ↑ Ross, JS.; Torres-Mora, J.; Wagle, N.; Jennings, TA.; Jones, DM. (Sep 2010). "Biomarker-based prediction of response to therapy for colorectal cancer: current perspective.". Am J Clin Pathol 134 (3): 478-90. doi:10.1309/AJCP2Y8KTDPOAORH. PMID 20716806.
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