Difference between revisions of "Glycogen-rich clear cell carcinoma of the breast"
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{{ Infobox diagnosis | |||
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| Micro = groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour, variable architecture (cords, trabeculae, clusters, cribriform), minimal nuclear pleomorphism | |||
| Subtypes = | |||
| LMDDx = [[signet-ring cell carcinoma]], lipid-rich carcinoma, [[apocrine carcinoma of the breast|apocrine carcinoma]],[[Secretory carcinoma of the breast|secretory carcinoma]] | |||
| Stains = PAS +ve, PASD -ve, Oil red O -ve | |||
| IHC = [[BRST2]] -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[breast grossing]] | |||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = similar to NST | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Glycogen-rich clear cell carcinoma of the breast''' is rare type of [[invasive breast cancer]]. | '''Glycogen-rich clear cell carcinoma of the breast''' is rare type of [[invasive breast cancer]]. | ||
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==General== | ==General== | ||
*Very rare. | *Very rare - fewer than 100 reported as cases in 2012.<ref name=pmid23904836>{{Cite journal | last1 = Salemis | first1 = NS. | title = Intraductal glycogen-rich clear cell carcinoma of the breast: a rare presentation and review of the literature. | journal = Breast Care (Basel) | volume = 7 | issue = 4 | pages = 319-21 | month = Aug | year = 2012 | doi = 10.1159/000341393 | PMID = 23904836 }}</ref> | ||
*Possibly a variant of [[apocrine carcinoma of the breast|apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi = | PMID = 7611537 }} | *Possibly a variant of [[apocrine carcinoma of the breast|apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi = | PMID = 7611537 }} | ||
</ref> | </ref> | ||
*Prognosis | *Prognosis similar to [[invasive ductal carcinoma of the breast|invasive ductal carcinoma]] in a smaller case-control study when matched for stage.<ref name=pmid24400866>{{Cite journal | last1 = Ma | first1 = X. | last2 = Han | first2 = Y. | last3 = Fan | first3 = Y. | last4 = Cao | first4 = X. | last5 = Wang | first5 = X. | title = Clinicopathologic Characteristics and Prognosis of Glycogen-Rich Clear Cell Carcinoma of the Breast. | journal = Breast J | volume = | issue = | pages = | month = Jan | year = 2014 | doi = 10.1111/tbj.12231 | PMID = 24400866 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
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DDx: | DDx: | ||
*[[Signet-ring carcinoma]]. | *[[Signet-ring cell carcinoma]]. | ||
*Lipid-rich carcinoma. | *Lipid-rich carcinoma. | ||
*[[Apocrine carcinoma of the breast|Apocrine carcinoma]]. | *[[Apocrine carcinoma of the breast|Apocrine carcinoma]]. | ||
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==IHC== | ==IHC== | ||
Features:<ref name= | Features:<ref name=pmid24400866/> | ||
*[[BRST2]] -ve. | *[[BRST2]] -ve.<ref name=pmid20551566/> | ||
**Apocrine carcinoma +ve. | **Apocrine carcinoma +ve. | ||
*ER +ve (~62% of cases). | |||
*PR +ve (~62% of cases). | |||
*HER2 -ve (~88% of cases). | |||
==See also== | ==See also== | ||
Latest revision as of 11:35, 8 September 2016
| Glycogen-rich clear cell carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour, variable architecture (cords, trabeculae, clusters, cribriform), minimal nuclear pleomorphism |
| LM DDx | signet-ring cell carcinoma, lipid-rich carcinoma, apocrine carcinoma,secretory carcinoma |
| Stains | PAS +ve, PASD -ve, Oil red O -ve |
| IHC | BRST2 -ve |
| Grossing notes | breast grossing |
| Staging | breast cancer staging |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | very rare |
| Prognosis | similar to NST |
Glycogen-rich clear cell carcinoma of the breast is rare type of invasive breast cancer.
It may be abbreviated GRCC.
General
- Very rare - fewer than 100 reported as cases in 2012.[1]
- Possibly a variant of apocrine carcinoma.[2]
- Prognosis similar to invasive ductal carcinoma in a smaller case-control study when matched for stage.[3]
Microscopic
Features:
- Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.[4]
- Various architectural arrangements: cords, trabeculae, clusters, cribriform.
- Minimal nuclear pleomorphism.
Notes:
- Histologic appearance may be similar to hyalinizing clear cell carcinoma.
DDx:
- Signet-ring cell carcinoma.
- Lipid-rich carcinoma.
- Apocrine carcinoma.
- Secretory carcinoma.
Images
www:
Stains
Features:[4]
- PAS +ve.
- PASD -ve.
Others:[4]
- Oil red O -ve.
- Lipid-rich carcinoma +ve.
IHC
Features:[3]
- BRST2 -ve.[4]
- Apocrine carcinoma +ve.
- ER +ve (~62% of cases).
- PR +ve (~62% of cases).
- HER2 -ve (~88% of cases).
See also
References
- ↑ Salemis, NS. (Aug 2012). "Intraductal glycogen-rich clear cell carcinoma of the breast: a rare presentation and review of the literature.". Breast Care (Basel) 7 (4): 319-21. doi:10.1159/000341393. PMID 23904836.
- ↑ Hayes, MM.; Seidman, JD.; Ashton, MA. (Aug 1995). "Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases.". Am J Surg Pathol 19 (8): 904-11. PMID 7611537.
- ↑ 3.0 3.1 Ma, X.; Han, Y.; Fan, Y.; Cao, X.; Wang, X. (Jan 2014). "Clinicopathologic Characteristics and Prognosis of Glycogen-Rich Clear Cell Carcinoma of the Breast.". Breast J. doi:10.1111/tbj.12231. PMID 24400866.
- ↑ 4.0 4.1 4.2 4.3 4.4 Thondavadi, SR.; Krishnamurthy, J.; Gubbanna, VM.. "A case report of glycogen-rich clear cell carcinoma of breast.". Indian J Pathol Microbiol 53 (2): 374-5. doi:10.4103/0377-4929.64289. PMID 20551566.