Difference between revisions of "Fibroadenoma"
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'''Fibroadenoma''' is a common benign tumour of the [[breast]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Breast fibradenoma (1).jpg | |||
| Width = | |||
| Caption = Fibroadenoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = abundant (intralobular) stroma usu. white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells | |||
| Subtypes = juvenile, complex, myxoid, cellular, tubular adenoma of the breast | |||
| LMDDx = [[phyllodes tumour]], [[sarcoma]], [[pseudoangiomatous stromal hyperplasia]], [[adenomyoepithelioma]] for [[tubular adenoma of the breast]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = well-circumscribed, rubbery, tan/white, +/-lobulated appearance, +/-short slit-like spaces, +/-calcifications | |||
| Grossing = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very common | |||
| Bloodwork = | |||
| Rads = typically BIRADS4 - see ''[[BIRADS]]'' | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other breast tumours - esp. [[phyllodes tumour]] | |||
| Tx = conservative excision | |||
}} | |||
'''Fibroadenoma''', abbreviated '''FA''', is a common benign tumour of the [[breast]]. | |||
It is a type of [[fibroepithelial tumours of the breast|fibroepithelial tumour]]. | |||
==General== | ==General== | ||
| Line 18: | Line 51: | ||
*+/-Calcification. | *+/-Calcification. | ||
Images | ===Images=== | ||
*[http://webpathology.com/image.asp?n=2&Case=276 Fibroadenoma - slit-like spaces (webpathology.com)]. | *[http://webpathology.com/image.asp?n=2&Case=276 Fibroadenoma - slit-like spaces (webpathology.com)]. | ||
*[http://webpathology.com/image.asp?case=276&n=3 Fibroadenoma - lobulated appearance (webpathology.com)]. | *[http://webpathology.com/image.asp?case=276&n=3 Fibroadenoma - lobulated appearance (webpathology.com)]. | ||
| Line 85: | Line 118: | ||
*Cellular. | *Cellular. | ||
*Mitoses. | *Mitoses. | ||
Note: | |||
*"Cellular" is something that can be subjective. One definition of "cellular" is: "stromal cells are touching one another". Jacobs ''et al.'' has a stromal cellularity picture gallery showing ''mild'' (rare stromal cells touching), ''moderate'' and ''marked'' (many stromal cells touching).<ref name=pmid16191502>{{Cite journal | last1 = Jacobs | first1 = TW. | last2 = Chen | first2 = YY. | last3 = Guinee | first3 = DG. | last4 = Holden | first4 = JA. | last5 = Cha | first5 = I. | last6 = Bauermeister | first6 = DE. | last7 = Hashimoto | first7 = B. | last8 = Wolverton | first8 = D. | last9 = Hartzog | first9 = G. | title = Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision? | journal = Am J Clin Pathol | volume = 124 | issue = 3 | pages = 342-54 | month = Sep | year = 2005 | doi = 10.1309/5N2C-4N5X-CB8X-W8JL | PMID = 16191502 }}</ref> | |||
====Complex fibroadenoma==== | ====Complex fibroadenoma==== | ||
| Line 101: | Line 137: | ||
====Tubular adenoma of the breast==== | ====Tubular adenoma of the breast==== | ||
*Considered by many a variant of ''fibroadenoma''. | *Considered by many a variant of ''fibroadenoma''. | ||
**[[IHC]] features of ''tubular adenoma of the breast'' and ''fibroadenoma'' are similar.<ref>{{Cite journal | last1 = Maiorano | first1 = E. | last2 = Albrizio | first2 = M. | title = Tubular adenoma of the breast: an immunohistochemical study of ten cases. | journal = Pathol Res Pract | volume = 191 | issue = 12 | pages = 1222-30 | month = Dec | year = 1995 | doi = | PMID = 8927570 }}</ref> | **[[IHC]] features of ''[[tubular adenoma]] of the breast'' and ''fibroadenoma'' are similar.<ref>{{Cite journal | last1 = Maiorano | first1 = E. | last2 = Albrizio | first2 = M. | title = Tubular adenoma of the breast: an immunohistochemical study of ten cases. | journal = Pathol Res Pract | volume = 191 | issue = 12 | pages = 1222-30 | month = Dec | year = 1995 | doi = | PMID = 8927570 }}</ref> | ||
*Most present in adults between menarche and menopause. | |||
Features:<ref name=Ref_BP116>{{Ref BP|116}}</ref> | Features:<ref name=Ref_BP116>{{Ref BP|116}}</ref> | ||
* | *Well circumscribed lesion. | ||
* | *Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer. | ||
*Stroma is generally more sparse than in conventional fibroadenoma | |||
Images: | Images: | ||
*[http://www.webpathology.com/image.asp?case=277&n=1 Tubular adenoma of the breast (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=277&n=1 Tubular adenoma of the breast (webpathology.com)]. | ||
<gallery> | <gallery> | ||
Image:Breast TubularAdenoma LP CTR.jpg|Breast - Tubular Adenoma - low power (SKB) | |||
Image:Breast TubularAdenoma MP CTR.jpg|Breast - Tubular Adenoma - medium power (SKB) | |||
Image:Breast TubularAdenoma HP CTR.jpg|Breast - Tubular Adenoma - high power (SKB) | |||
Image:Breast TubularAdenoma LP SNP.jpg|Breast - Tubular Adenoma - low power (SKB) | |||
Image:Breast TubularAdenoma MP SNP.jpg|Breast - Tubular Adenoma - medium power (SKB) | |||
Image:Breast TubularAdenoma LactationalChange pa.JPG|Breast - Tubular Adenoma with lactational change (SKB) | |||
Image:Tubular_Adenoma_of_Breast_(myosin_immunostain)_(4351463966).jpg | TA of the breast - myosin IHC. (WC) | Image:Tubular_Adenoma_of_Breast_(myosin_immunostain)_(4351463966).jpg | TA of the breast - myosin IHC. (WC) | ||
</gallery> | </gallery> | ||
==Sign out== | |||
<pre> | |||
Right Partial Breast, Lumpectomy: | |||
- Fibroadenoma. | |||
</pre> | |||
====Micro==== | |||
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. No apparent proliferative activity is present. The border is well-circumscribed where seen. Focally, the lesion approaches the inked margin; partial lesion transection cannot be excluded. | |||
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen. | |||
===Complex=== | |||
<pre> | |||
Right Breast, Lumpectomy: | |||
- Complex fibroadenoma with apocrine metaplasia. | |||
- Negative for carcinoma in situ and negative for malignancy. | |||
</pre> | |||
====Micro==== | |||
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. Minimal mitotic activity is present (2 mitosis/10 HPF, where 1 HPF ~ 0.2376 mm*mm). The border is well-circumscribed where seen. The lesion was shelled-out. | |||
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen. | |||
==See also== | ==See also== | ||
Latest revision as of 19:25, 5 January 2021
| Fibroadenoma | |
|---|---|
| Diagnosis in short | |
.jpg) Fibroadenoma. H&E stain. | |
|
| |
| LM | abundant (intralobular) stroma usu. white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells |
| Subtypes | juvenile, complex, myxoid, cellular, tubular adenoma of the breast |
| LM DDx | phyllodes tumour, sarcoma, pseudoangiomatous stromal hyperplasia, adenomyoepithelioma for tubular adenoma of the breast |
| Gross | well-circumscribed, rubbery, tan/white, +/-lobulated appearance, +/-short slit-like spaces, +/-calcifications |
| Site | breast |
|
| |
| Prevalence | very common |
| Radiology | typically BIRADS4 - see BIRADS |
| Prognosis | benign |
| Clin. DDx | other breast tumours - esp. phyllodes tumour |
| Treatment | conservative excision |
Fibroadenoma, abbreviated FA, is a common benign tumour of the breast.
It is a type of fibroepithelial tumour.
General
- Very common benign finding.
- The pathology is in the stroma; so, the lesion is really a misnomer by the naming rules.
- It ought to be called adenofibroma (as a few occasionally do[1]), as the glandular component is benign and the stromal component lesional; there is no truth in names in pathology.
Management:
- Local excision -- without a large margin.
Gross
Features:[2]
- Well-circumscribed.
- Rubbery - classic descriptor.
- Tan/white.
- +/-Lobulated appearance.
- +/-Slit-like spaces - short.
- +/-Calcification.
Images
- Fibroadenoma - slit-like spaces (webpathology.com).
- Fibroadenoma - lobulated appearance (webpathology.com).
- Fibroadenoma (surgical-tutor.org).
Microscopic
Features:[3]
- Abundant (intralobular) stroma - most key feature.
- Stroma is usually:
- White/pale, i.e. myxoid, on H&E (normal stroma is pink).
- May be hyalinized (dark pink) if infarcted.
- Paucicellular - typical.
- White/pale, i.e. myxoid, on H&E (normal stroma is pink).
- Stroma is usually:
- Compression of glandular elements - very commonly seen.
- Glandular elements have at least two cell layers - epithelial and myoepithelial.
Notes:
- There is stuff about intracanalicular vs. pericanalicular.[4] It is irrelevant; there is no prognostic difference between the two.
- Do not comment on the margin - it is irrelevant.
DDx:
- Phyllodes tumour - long slit-like spaces (seen grossly), stroma is more cellular.
- +/-Mitoses,
- +/-"Stromal overgrowth" = large area where there is a 'loss of glands'.
- Sarcoma.
- Pseudoangiomatous stromal hyperplasia.
- Small capillary-like structures in the stroma.
- Epithelial component often not compressed - as in fibroadenoma.
- Small capillary-like structures in the stroma.
- Adenomyoepithelioma - for tubular adenoma of the breast.
Images
Fibroadenoma. (WC/KGH)
Fibroadenoma. (WC/KGH)
.jpg)
www:
Variants
Four variants are described by the Washington Manual:[7]
- Juvenile.
- Complex.
- Myxoid.
- Cellular.
Considered a variant of fibroadenoma by many authorities:[8]
Juvenile fibroadenoma
- As the name suggests, is typically found in younger patients.
- Classic history: rapid growth.
Features (juvenile variant):[9]
- Stromal and epithelial hyperplasia - key feature.
- +/-Tapering, thin micropapillae (gynecomastoid hyperplasia).[8]
- Mitoses uncommon.
Myxoid fibroadenoma
- May be associated with Carney's complex.
Features:
Cellular fibroadenoma
Features (cellular variant):
- Cellular.
- Mitoses.
Note:
- "Cellular" is something that can be subjective. One definition of "cellular" is: "stromal cells are touching one another". Jacobs et al. has a stromal cellularity picture gallery showing mild (rare stromal cells touching), moderate and marked (many stromal cells touching).[10]
Complex fibroadenoma
- Contain proliferative epithelium which outside and inside a fibroadenoma is associated with an increased risk of malignancy.
Features:[11]
- Apocrine metaplasia.
- Cysts > 3 mm.
- Calcification.
- Sclerosing adenosis.
Memory devices:
- FACS: complex fibroadenoma, apocrine metaplasia, calcs & cysts, sclerosing adenosis.
- CAMS: calcs, apocrine metaplasia, microcysts, sclerosing adenosis.
Tubular adenoma of the breast
- Considered by many a variant of fibroadenoma.
- IHC features of tubular adenoma of the breast and fibroadenoma are similar.[12]
- Most present in adults between menarche and menopause.
Features:[8]
- Well circumscribed lesion.
- Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer.
- Stroma is generally more sparse than in conventional fibroadenoma
Images:
Breast - Tubular Adenoma - low power (SKB)
Breast - Tubular Adenoma - medium power (SKB)
Breast - Tubular Adenoma - high power (SKB)
Breast - Tubular Adenoma - low power (SKB)
Breast - Tubular Adenoma - medium power (SKB)
Breast - Tubular Adenoma with lactational change (SKB)
TA of the breast - myosin IHC. (WC)
_(4351463966).jpg)
Sign out
Right Partial Breast, Lumpectomy: - Fibroadenoma.
Micro
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. No apparent proliferative activity is present. The border is well-circumscribed where seen. Focally, the lesion approaches the inked margin; partial lesion transection cannot be excluded.
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen.
Complex
Right Breast, Lumpectomy: - Complex fibroadenoma with apocrine metaplasia. - Negative for carcinoma in situ and negative for malignancy.
Micro
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. Minimal mitotic activity is present (2 mitosis/10 HPF, where 1 HPF ~ 0.2376 mm*mm). The border is well-circumscribed where seen. The lesion was shelled-out.
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen.
See also
References
- ↑ Guinebretière, JM.; Menet, E.; Tardivon, A.; Cherel, P.; Vanel, D. (Apr 2005). "Normal and pathological breast, the histological basis.". Eur J Radiol 54 (1): 6-14. doi:10.1016/j.ejrad.2004.11.020. PMID 15797289.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 550. ISBN 978-1416054542.
- ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 110. ISBN 978-0443066801.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970216-9. Accessed on: 16 March 2011.
- ↑ Sabate, JM.; Clotet, M.; Torrubia, S.; Gomez, A.; Guerrero, R.; de las Heras, P.; Lerma, E. (Oct 2007). "Radiologic evaluation of breast disorders related to pregnancy and lactation.". Radiographics 27 Suppl 1: S101-24. doi:10.1148/rg.27si075505. PMID 18180221.
- ↑ URL: http://www.imagingpathways.health.wa.gov.au/includes/dipmenu/image/image.html. Accessed on: 15 February 2012.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 262. ISBN 978-0781765275.
- ↑ 8.0 8.1 8.2 O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 116. ISBN 978-0443066801.
- ↑ URL: http://www.breastpathology.info/fibro_variants.html#juvenile. Accessed on: 3 October 2011.
- ↑ Jacobs, TW.; Chen, YY.; Guinee, DG.; Holden, JA.; Cha, I.; Bauermeister, DE.; Hashimoto, B.; Wolverton, D. et al. (Sep 2005). "Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision?". Am J Clin Pathol 124 (3): 342-54. doi:10.1309/5N2C-4N5X-CB8X-W8JL. PMID 16191502.
- ↑ URL: http://www.breastpathology.info/fibro_variants.html#complex. Accessed on: 3 October 2011.
- ↑ Maiorano, E.; Albrizio, M. (Dec 1995). "Tubular adenoma of the breast: an immunohistochemical study of ten cases.". Pathol Res Pract 191 (12): 1222-30. PMID 8927570.