Prostatic stromal tumour of uncertain malignant potential

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Prostatic stromal tumour of uncertain malignant potential, abbreviated PSTUMP, is a rare lesion of the prostatic stroma which cannot be definitively classified as benign or malignant.

It may be abbreviated as STUMP;[1] an abbreviation used for a uterine lesion of uncertain malignant potential.

It is also known as prostatic stromal proliferation of uncertain malignant potential (abbreviated PSPUMP).[2]

General

  • Rare.

Microscopic

Features:

  • Overgrowth of spindle cells - "hypercellular stroma" - key feature.[1]
  • +/-Atypical nuclei.[1]
  • +/-Multinucleation.

Note:

  • Do not have necrosis and no or minimal mitotic activity - important.[1]
  • May be seen with glandular abnormalities.[3]

DDx:

Subclassification

May be subclassified as per Gaudin et al.:[2]

  1. Scattered atypical cells with benign glands.
  2. Minimal atypical cells.
  3. Leaf like growth pattern (phyllodes-like).
  4. Atypical cells without glands.

Images

IHC

Features:[1]

  • ER +ve.
  • PR +ve.
  • Desmin +ve/-ve.
  • CD34 +ve.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 De Berardinis, E.; Busetto, GM.; Antonini, G.; Giovannone, R.; Di Placido, M.; Magliocca, FM.; Di Silverio, A.; Gentile, V. (2012). "Incidental prostatic stromal tumor of uncertain malignant potential (STUMP): histopathological and immunohistochemical findings.". Urologia 79 (1): 65-8. doi:10.5301/RU.2012.9099. PMID 22388992.
  2. 2.0 2.1 Gaudin, PB.; Rosai, J.; Epstein, JI. (Feb 1998). "Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases.". Am J Surg Pathol 22 (2): 148-62. PMID 9500215. Cite error: Invalid <ref> tag; name "pmid9500215" defined multiple times with different content
  3. Nagar, M.; Epstein, JI. (Jun 2011). "Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP).". Am J Surg Pathol 35 (6): 898-903. doi:10.1097/PAS.0b013e318214f2f2. PMID 21572264.
  4. Murer, LM.; Talmon, GA. (Nov 2014). "Stromal tumor of uncertain malignant potential of the prostate.". Arch Pathol Lab Med 138 (11): 1542-5. doi:10.5858/arpa.2013-0212-RS. PMID 25357117.