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Difference between revisions of "Invasive breast cancer"
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→Microscopic
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**May have a thick fibrous capsule = ''encapsulated papillary carcinoma''.<ref name=pmid21057133/> | **May have a thick fibrous capsule = ''encapsulated papillary carcinoma''.<ref name=pmid21057133/> | ||
*Loss of myoepithelial cells - '''key feature'''. | *Loss of myoepithelial cells - '''key feature'''. | ||
*Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | |||
</ref>. | |||
**These cells are so-called globoid cells or clear cells and are immunoreactive for GCDFP-15. | |||
**They should not be mistaken for myoepithelial cells. | |||
*Neoplastic epithelial cells: | *Neoplastic epithelial cells: | ||
**[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]]. | **[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]]. | ||