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Difference between revisions of "Invasive breast cancer"
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→HER2 scoring: sortable
m (→HER2 scoring: sortable) |
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===HER2 scoring=== | ===HER2 scoring=== | ||
Immunohistochemical based testing:<ref name=Ref_Lester241-2>{{Ref Lester|241-2}}</ref><ref name=Lester3_87>{{Ref Lester3|87}}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf]. Accessed on: 27 November 2011.</ref> | Immunohistochemical based testing:<ref name=Ref_Lester241-2>{{Ref Lester|241-2}}</ref><ref name=Lester3_87>{{Ref Lester3|87}}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2009/InvasiveBreast_09protocol.pdf]. Accessed on: 27 November 2011.</ref> | ||
{| class="wikitable" | {| class="wikitable sortable" | ||
! Score | |||
! Staining intensity | |||
! Cells stained (%) | |||
! Membrane staining | |||
! Management | |||
! Percentage of cases | |||
|- | |- | ||
| '''0''' | | '''0''' | ||
| nil | | nil | ||
| <=10% | | '''<=10%''' | ||
| incomplete | | '''incomplete''' | ||
| No HER2 blocker | | No HER2 blocker | ||
| ~60% | | ~60% | ||
| Line 321: | Line 321: | ||
| '''1+''' | | '''1+''' | ||
| minimal-to-weak | | minimal-to-weak | ||
| >10% | | '''>10%''' | ||
| incomplete | | '''incomplete''' | ||
| No HER2 blocker | | No HER2 blocker | ||
| ~10% | | ~10% | ||
| Line 328: | Line 328: | ||
| '''2+''' | | '''2+''' | ||
| weak-to-moderate ''or'' intense | | weak-to-moderate ''or'' intense | ||
| >10% | | '''>10% ''and'' <=30%''' | ||
| complete | | '''complete''' | ||
| Needs [[SISH]] or [[FISH]] | | Needs [[SISH]] or [[FISH]] | ||
| ~10% | | ~10% | ||
| Line 335: | Line 335: | ||
| '''3+''' | | '''3+''' | ||
| intense & uniform staining (used to be ''strong'') | | intense & uniform staining (used to be ''strong'') | ||
| >30% (used to ''>10%'') | | '''>30%''' (used to ''>10%'') | ||
| complete | | '''complete''' | ||
| HER2 blocker | | HER2 blocker | ||
| ~20% | | ~20% | ||
| Line 349: | Line 349: | ||
ISH based testing:<ref name=Lester3_87>{{Ref Lester3|87}}</ref> | ISH based testing:<ref name=Lester3_87>{{Ref Lester3|87}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
! Result | |||
! Ratio criteria | |||
! Gene copy number criteria | |||
|- | |- | ||
| Positive | | Positive | ||