Sclerosing adenosis of the breast
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Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.
| Sclerosing adenosis of the breast | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini |
| LM DDx | low-grade ductal carcinoma, tubular adenoma of the breast, adenomyoepithelioma, breast adenosis |
| Site | breast |
|
| |
| Prevalence | common |
| Prognosis | benign, increased risk of breast cancer |
General
- Can be scary... can look like ductal carcinoma.
- Derived from sclerosing[1] (hardening) and adenosis (glandular enlargement).
- Think scaring + lotsa glands and you're pretty close.
- Management: follow-up, no further treatment.[2]
Microscopic
Features:
- Acini are smaller than usual and there are more of them.
- Acini often slit-like.
- Fibrosis (scleroses) - pink on H&E surrounds the acini.
- Can mimic a desmoplastic reaction.
Notes:
- The acini should:
- Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
- Have two cell layers like well-behaved breast glands do.
DDx:
- Low-grade ductal carcinoma.
- Tubular adenoma of the breast.
- Adenomyoepithelioma.[3]
- Breast adenosis - should have visble lumens.
Images
SA - low mag. (WC)
SA - intermed. mag. (WC)
SA - high mag. (WC)
SA - very high mag. (WC)
See also
References
- ↑ URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
- ↑ URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
- ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.