Clear cell tumours

Clear cell tumours are found in a number of organs. Thus, it is important to have a list of 'em in one's head so one doesn't misdiagnose something.

Hyalinizing clear cell carcinoma, a rare clear cell tumour. H&E stain. (WC/Nephron)

Clear cell in the name

Skin

Clear cell carcinoma of the skin.

Gynecologic tract

Clear cell carcinoma of the gynecologic tract.

Genitourinary tract

Gastrointestinal tract

Clear cell variant of hepatocellular carcinoma.^[1]

Head and neck pathology

Clear cell carcinoma of the salivary gland:^[2]
- Clear cell myoepithelial carcinoma.
- Hyalinizing clear cell carcinoma.

Soft tissue pathology

Clear cell sarcoma.

Neuropathology

Clear cell meningioma.

Tumours with clear/pale cytoplasm

An exhaustive differential diagnosis for clear cell tumour

Adapted from Miller with modifications:^[3]

Tumour	Group	Notes/comments
Clear cell renal cell carcinoma	Clear cell carcinoma
Lung	Clear cell carcinoma
Pulmonary blastoma	Other
Bladder	Clear cell carcinoma
Clear cell carcinoma of the salivary gland	Clear cell carcinoma
Breast	Clear cell carcinoma
Ovarian clear cell carcinoma	Clear cell carcinoma
Endometrial clear cell carcinoma	Clear cell carcinoma
Paratesticular tissues	Clear cell carcinoma
Adrenal	Clear cell carcinoma
Prostate	Clear cell carcinoma
Hepatocellular carcinoma	Clear cell carcinoma
GI tract	Clear cell carcinoma
Pancreas	Clear cell carcinoma
Clear cell squamous carcinoma	Other carcinomas
Hyalinizing clear cell carinoma of salivary gland	Other carcinomas
Adnexal clear cell carcinoma with comedonecrosis	Other carcinomas
Clear cell follicular carcinoma of thyroid	Other carcinomas
Acinar cell carcinoma	Other carcinomas
Cholangiocarcinoma	Other carcinomas	^[4]
Atypical bile duct adenoma, clear cell type	Epithelial lesion	^[5]
Clear cell carcinoid	Clear cell neuroendocrine tumours
Clear cell pancreatic endocrine neoplasm	Clear cell neuroendocrine tumours
Clear cell medullary carcinoma of the thyroid	Clear cell neuroendocrine tumours
Clear cell paraganglioma of prostate	Clear cell neuroendocrine tumours
Clear cell lymphoma	Clear cell Hematolymphoid
Clear cell myeloma	Clear cell Hematolymphoid
Syncytial Hodgkin's lymphoma	Clear cell Hematolymphoid
Seminoma	Germ cell tumours
Yolk sac tumour	Germ cell tumours
Clear cell sex-cord stromal tumours	Other	Leydig cell tumour
Clear cell thymoma	Other
Clear cell mesothelioma	Other
Solid pseudopapillary tumour of pancreas	Other	^[6]
Clear cell oncocytoma of salivary gland	Other epithelial clear cell tumours
Chordoma	Other epithelial clear cell tumours
Giant notochrodal hamartoma	Other epithelial clear cell tumours
Clear cell melanoma	Melanoma
Clear cell PEComas - "sugar" tumor (lung, heart, pancreas, skin, soft tissue)	Other
Clear cell sarcoma	mesenchymal tumours
Clear cell dermatofibroma	mesenchymal tumours
Clear cell atypical fibroxanthoma	mesenchymal tumours
Clear cell meningioma	mesenchymal tumours	^[7]
Dermal clear cell mesenchymal neoplasm	mesenchymal tumours	^[8]
Clear cell GIST	mesenchymal tumours
Alveolar soft part sarcoma	mesenchymal tumours
Reticular variant of perineurioma	mesenchymal tumours	EMA +ve
Lipidized fibrous histiocytoma	mesenchymal tumours	^[9]
Clear cell dermatofibroma	mesenchymal tumours
Clear cell or "lipidized" fibrous papule of the nose	mesenchymal tumours

References

↑ Murakata, LA.; Ishak, KG.; Nzeako, UC. (Aug 2000). "Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma.". Mod Pathol 13 (8): 874-81. doi:10.1038/modpathol.3880156. PMID 10955454.
↑ Wang, B.; Brandwein, M.; Gordon, R.; Robinson, R.; Urken, M.; Zarbo, RJ. (Jun 2002). "Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma.". Arch Pathol Lab Med 126 (6): 676-85. doi:10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2. PMID 12033955.
↑ Miller RT. (Sep 2013). Atlantic Diagnostic Immunohistochemistry Symposium. St. John's, NL, Canada.
↑ Haas, S.; Gütgemann, I.; Wolff, M.; Fischer, HP. (Jun 2007). "Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma.". Am J Surg Pathol 31 (6): 902-6. doi:10.1097/PAS.0b013e31802c0c8a. PMID 17527078.
↑ Albores-Saavedra, J.; Hoang, MP.; Murakata, LA.; Sinkre, P.; Yaziji, H. (Jul 2001). "Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver.". Am J Surg Pathol 25 (7): 956-60. PMID 11420469.
↑ Albores-Saavedra, J.; Simpson, KW.; Bilello, SJ. (Oct 2006). "The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm.". Am J Surg Pathol 30 (10): 1237-42. doi:10.1097/01.pas.0000209849.97787.e0. PMID 17001153.
↑ Carlotti, CG.; Neder, L.; Colli, BO.; dos Santos, MB.; Garcia, AS.; Elias, J.; Chimelli, LC. (Jan 2003). "Clear cell meningioma of the fourth ventricle.". Am J Surg Pathol 27 (1): 131-5. PMID 12502936.
↑ Lazar, AJ.; Fletcher, CD. (Aug 2004). "Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases.". Am J Dermatopathol 26 (4): 273-9. PMID 15249856.
↑ Iwata, J.; Fletcher, CD. (Apr 2000). "Lipidized fibrous histiocytoma: clinicopathologic analysis of 22 cases.". Am J Dermatopathol 22 (2): 126-34. PMID 10770432.

[pmid10955454-1] Murakata, LA.; Ishak, KG.; Nzeako, UC. (Aug 2000). "Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma.". Mod Pathol 13 (8): 874-81. doi:10.1038/modpathol.3880156. PMID 10955454.

[pmid12033955-2] Wang, B.; Brandwein, M.; Gordon, R.; Robinson, R.; Urken, M.; Zarbo, RJ. (Jun 2002). "Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma.". Arch Pathol Lab Med 126 (6): 676-85. doi:10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2. PMID 12033955.

[miller-3] Miller RT. (Sep 2013). Atlantic Diagnostic Immunohistochemistry Symposium. St. John's, NL, Canada.

[4] Haas, S.; Gütgemann, I.; Wolff, M.; Fischer, HP. (Jun 2007). "Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma.". Am J Surg Pathol 31 (6): 902-6. doi:10.1097/PAS.0b013e31802c0c8a. PMID 17527078.

[5] Albores-Saavedra, J.; Hoang, MP.; Murakata, LA.; Sinkre, P.; Yaziji, H. (Jul 2001). "Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver.". Am J Surg Pathol 25 (7): 956-60. PMID 11420469.

[6] Albores-Saavedra, J.; Simpson, KW.; Bilello, SJ. (Oct 2006). "The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm.". Am J Surg Pathol 30 (10): 1237-42. doi:10.1097/01.pas.0000209849.97787.e0. PMID 17001153.

[7] Carlotti, CG.; Neder, L.; Colli, BO.; dos Santos, MB.; Garcia, AS.; Elias, J.; Chimelli, LC. (Jan 2003). "Clear cell meningioma of the fourth ventricle.". Am J Surg Pathol 27 (1): 131-5. PMID 12502936.

[8] Lazar, AJ.; Fletcher, CD. (Aug 2004). "Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases.". Am J Dermatopathol 26 (4): 273-9. PMID 15249856.

[9] Iwata, J.; Fletcher, CD. (Apr 2000). "Lipidized fibrous histiocytoma: clinicopathologic analysis of 22 cases.". Am J Dermatopathol 22 (2): 126-34. PMID 10770432.

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