Foamy gland carcinoma
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Foamy gland carcinoma, also foamy gland adenocarcinoma,[1] is an uncommon variant of prostate carcinoma that has a bland appearance and may be confused with benign glands.
| Foamy gland carcinoma | |
|---|---|
| Diagnosis in short | |
 Foamy gland carcinoma. H&E stain. | |
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| |
| Synonyms | foamy gland adenocarcinoma |
| Subtypes | (subtype of prostate carcinoma) |
| LM DDx | adenosis of the prostate, bulbourethral gland, pseudohyperplastic adenocarcinoma |
| IHC | AMACR +ve, CK5/6 -ve, p63 -ve |
| Gross | see prostate carcinoma |
| Grossing notes | see prostate carcinoma |
| Site | prostate gland - see prostate carcinoma |
|
| |
| Syndromes | see prostate carcinoma |
|
| |
| Prevalence | uncommon |
| Prognosis | often good, dependent on Gleason score & stage |
| Clin. DDx | see prostate carcinoma |
| Treatment | see prostate carcinoma |
General
- Rare.
- Usually low grade, i.e. Gleason score 6/10.[1]
Microscopic
Features:
- Increased glandular density - key feature.
- Eosinophilic intraluminal amorphous secretions - key feature.
- Abundant foamy cytoplasm.
- Tufted glandular border.
- Gland size larger than "typical" prostate cancer.
Note:
- Prominent nucleoli usually infrequent or absent![1]
- Can be thought of as pseudohyperplastic adenocarcinoma without the nucleoli.
DDx:
Images
Intraluminal eosinophilic crystalloid in foamy glands. (WC)
www: