Sclerosing adenosis of the breast
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Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.
General
- Can be scary... can look like ductal carcinoma.
- Derived from sclerosing[1] (hardening) and adenosis (glandular enlargement).
- Think scaring + lotsa glands and you're pretty close.
- Management: follow-up, no further treatment.[2]
Microscopic
Features:
- Acini are smaller than usual and there are more of them.
- Acini often slit-like.
- Fibrosis (scleroses) - pink on H&E surrounds the acini.
- Can mimic a desmoplastic reaction.
Notes:
- The acini should:
- Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
- Have two cell layers like well-behaved breast glands do.
DDx:
- Low-grade ductal carcinoma.
- Tubular adenoma of the breast.
- Adenomyoepithelioma.[3]
- Breast adenosis - should have visble lumens.
See also
References
- ↑ URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
- ↑ URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
- ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.