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Difference between revisions of "Chondro-osseous tumours"
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→Microscopic: tweak micro
(→IHC: +FLI-1) |
m (→Microscopic: tweak micro) |
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>IAV. 26 February 2009.</ref><ref name=Ref_Klatt417>{{Ref Klatt|417}}</ref> | Features:<ref>IAV. 26 February 2009.</ref><ref name=Ref_Klatt417>{{Ref Klatt|417}}</ref> | ||
*"Abnormal cartilage" | *"Abnormal cartilage": | ||
**Nuclear atypia. | **+/-Nuclear atypia - high grade lesions. | ||
***Nuclear clearing. | ***High grade lesions: | ||
***Nucleoli. | ****Nuclear clearing. | ||
****Nucleoli. | |||
****Hyperchromasia. | |||
***Low/intermediate grade lesions: | |||
****Bi-nucleation. | |||
****Hypochromatic enlarged nuclei. | |||
**Increased cellularity. | |||
***More cellular than cartilage... but relatively paucicellular compared to other sarcomas. | |||
**Irregular spacing of chondrocytes. | |||
Notes: | Notes: | ||
* | *Low grade chondrosarcoma are not cytologically malignant; the diagnosis rests mostly on radiologic findings. | ||
Images: | Images: | ||
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DDx: | DDx: | ||
*[[Chordoma]]. | *[[Chordoma]]. | ||
*[[Enchondroma]]. | |||
====Variants==== | ====Variants==== | ||
| Line 147: | Line 156: | ||
====Grading==== | ====Grading==== | ||
Features:<ref name=Ref_WMSP643>{{Ref WMSP|643}}</ref> | Features:<ref name=Ref_WMSP643>{{Ref WMSP|643}}</ref> | ||
*Grade I: moderate cellularity +/- binucleated cells. | *Grade I: mild-to-moderate increase of cellularity +/- binucleated cells. | ||
*Grade II: between Grade I and Grade III. | |||
*Grade III: nuclear pleomorphism, mitoses common. | *Grade III: nuclear pleomorphism, mitoses common. | ||
===IHC=== | ===IHC=== | ||