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|Diagnosis in short|
Enchondroma. H&E stain.
|LM||cytologically benign cells is spaced nests, should not extend into surrounding soft tissue|
|LM DDx||low-grade chondrosarcoma|
|Site||cartilage - see chondro-osseous tumours|
|Syndromes||Ollier disease, Maffucci syndrome, metachondromatosis|
Chondroma is a benign tumour of cartilage. It is in the chondro-osseous tumours group of soft tissue tumours.
- Benign thingy.
- Usual legs and feet.
- May be difficult to separate from chondrosarcoma.
- Multiple chondromas = enchondromatosis; three distinct syndromes:
- Ollier disease.
- Maffucci syndrome - with hemangiomas, increased risk of chondrosarcoma.
- Metachondromatosis - autosomal dominant.
- Enchondroma = chondroma in the marrow space.
- Lytic lesion.
- Usual close to a growth plate.
Important suspicious findings that favour malignant:
- Cortical destruction.
- Soft tissue component.
- High-grade chondroid lesions (high-grade chondrosarcoma) can usually be separated radiologically from low-grade ones.
- Cytologically benign cells is spaced nests.
- Should not extending into surrounding soft tissue.
- Low-grade chondrosarcoma - should be considered, correlation with radiology essential.
TISSUE ("CHONDROMA"), LEFT COSTAL MARGIN, EXCISION: - CHONDROMA.
The sections show spaced small cells in a pale matrix with a light-blue tinge. No nuclear atypia is appreciated. No mitotic activity is apparent. Degenerative changes are seen focally.
A small focus of cholesterol clefts with giant cells is present. Benign bone, bone marrow and skeletal muscle are present.
- ↑ 1.0 1.1 1.2 URL: http://emedicine.medscape.com/article/389224-overview. Accessed on: 25 December 2010.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 166000
- ↑ Choi, BB.; Jee, WH.; Sunwoo, HJ.; Cho, JH.; Kim, JY.; Chun, KA.; Hong, SJ.; Chung, HW. et al. "MR differentiation of low-grade chondrosarcoma from enchondroma.". Clin Imaging 37 (3): 542-7. doi:10.1016/j.clinimag.2012.08.006. PMID 23041161.
- ↑ Berber, O.; Datta, G.; Sabharwal, S.; Aston, W.; Saifuddin, A.; Briggs, T. (Apr 2012). "The safety of direct primary excision of low-grade chondral lesions based on radiological diagnosis alone.". Acta Orthop Belg 78 (2): 254-62. PMID 22696998.