Difference between revisions of "Foamy gland carcinoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Intraluminal eosinophilic crystalloid of prostate gland - high mag.jpg
| Width      =
| Caption    = Foamy gland carcinoma. [[H&E stain]].
| Synonyms  = foamy gland adenocarcinoma
| Micro      =
| Subtypes  = (subtype of [[prostate carcinoma]])
| LMDDx      = [[adenosis of the prostate]], [[bulbourethral gland]], [[pseudohyperplastic adenocarcinoma]]
| Stains    =
| IHC        = AMACR +ve, CK5/6 -ve, p63 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      = see ''[[prostate carcinoma]]''
| Grossing  = see ''[[prostate carcinoma]]''
| Site      = [[prostate gland]] - see ''[[prostate carcinoma]]''
| Assdx      =
| Syndromes  = see ''[[prostate carcinoma]]''
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = often good, dependent on Gleason score & stage
| Other      =
| ClinDDx    = see ''[[prostate carcinoma]]''
| Tx        = see ''[[prostate carcinoma]]''
}}
'''Foamy gland carcinoma''', also '''foamy gland adenocarcinoma''',<ref name=pmid19033862/> is an uncommon variant of [[prostate carcinoma]] that has a bland appearance and may be confused with benign glands.
'''Foamy gland carcinoma''', also '''foamy gland adenocarcinoma''',<ref name=pmid19033862/> is an uncommon variant of [[prostate carcinoma]] that has a bland appearance and may be confused with benign glands.



Revision as of 02:10, 23 October 2014

Foamy gland carcinoma
Diagnosis in short

Foamy gland carcinoma. H&E stain.

Synonyms foamy gland adenocarcinoma
Subtypes (subtype of prostate carcinoma)
LM DDx adenosis of the prostate, bulbourethral gland, pseudohyperplastic adenocarcinoma
IHC AMACR +ve, CK5/6 -ve, p63 -ve
Gross see prostate carcinoma
Grossing notes see prostate carcinoma
Site prostate gland - see prostate carcinoma

Syndromes see prostate carcinoma

Prevalence uncommon
Prognosis often good, dependent on Gleason score & stage
Clin. DDx see prostate carcinoma
Treatment see prostate carcinoma

Foamy gland carcinoma, also foamy gland adenocarcinoma,[1] is an uncommon variant of prostate carcinoma that has a bland appearance and may be confused with benign glands.

General

  • Rare.
  • Usually low grade, i.e. Gleason score 6/10.[1]

Microscopic

Features:

  • Increased glandular density - key feature.
  • Eosinophilic intraluminal amorphous secretions - key feature.
  • Abundant foamy cytoplasm.
  • Tufted glandular border.
  • Gland size larger than "typical" prostate cancer.

Note:

DDx:

Images

www:

See also

References

  1. 1.0 1.1 1.2 Zhao, J.; Epstein, JI. (Apr 2009). "High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases.". Am J Surg Pathol 33 (4): 583-90. doi:10.1097/PAS.0b013e31818a5c6c. PMID 19033862.