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Difference between revisions of "Cholangiocarcinoma"
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Notes: | Notes: | ||
*Biliary stents lead to reactive changes,<ref name=pmid3877438>{{Cite journal | last1 = Carrasco | first1 = CH | last2 = Wallace | first2 = S | last3 = Charnsangavej | first3 = C | last4 = Richli | first4 = W | last5 = Wright | first5 = KC | last6 = Fanning | first6 = T | last7 = Gianturco | first7 = C | title = Expandable biliary endoprosthesis: an experimental study. | journal = AJR Am J Roentgenol | volume = 145 | issue = 6 | pages = 1279-81 | month = Dec | year = 1985 | doi = | PMID = 3877438 }}</ref> these can be confused for malignancy. One must always check whether a biliary stent was in situ at time of biopsy.<ref>STC. 2 October 2009.</ref> | *Biliary stents lead to reactive changes,<ref name=pmid3877438>{{Cite journal | last1 = Carrasco | first1 = CH | last2 = Wallace | first2 = S | last3 = Charnsangavej | first3 = C | last4 = Richli | first4 = W | last5 = Wright | first5 = KC | last6 = Fanning | first6 = T | last7 = Gianturco | first7 = C | title = Expandable biliary endoprosthesis: an experimental study. | journal = AJR Am J Roentgenol | volume = 145 | issue = 6 | pages = 1279-81 | month = Dec | year = 1985 | doi = | PMID = 3877438 }}</ref> these can be confused for malignancy. One must always check whether a biliary stent was in situ at time of biopsy.<ref>STC. 2 October 2009.</ref> | ||
*Usually abundant desmoplasia, ergo hard to get good, i.e. diagnositic, endoluminal brushing specimens.<ref>STC. 6 December 2010.</ref> | *Usually abundant desmoplasia, ergo hard to get good, i.e. diagnositic, endoluminal brushing specimens.<ref name=stc6dec2010>STC. 6 December 2010.</ref> | ||
*May have hyaline inclusions.<ref name=pmid20716803>{{Cite journal | last1 = Aishima | first1 = S. | last2 = Fujita | first2 = N. | last3 = Mano | first3 = Y. | last4 = Iguchi | first4 = T. | last5 = Taketomi | first5 = A. | last6 = Maehara | first6 = Y. | last7 = Oda | first7 = Y. | last8 = Tsuneyoshi | first8 = M. | title = p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 457-65 | month = Sep | year = 2010 | doi = 10.1309/AJCP53YVVJCNDZIR | PMID = 20716803 | URL = http://ajcp.ascpjournals.org/content/134/3/457.full.pdf }} | *May have hyaline inclusions.<ref name=pmid20716803>{{Cite journal | last1 = Aishima | first1 = S. | last2 = Fujita | first2 = N. | last3 = Mano | first3 = Y. | last4 = Iguchi | first4 = T. | last5 = Taketomi | first5 = A. | last6 = Maehara | first6 = Y. | last7 = Oda | first7 = Y. | last8 = Tsuneyoshi | first8 = M. | title = p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 457-65 | month = Sep | year = 2010 | doi = 10.1309/AJCP53YVVJCNDZIR | PMID = 20716803 | URL = http://ajcp.ascpjournals.org/content/134/3/457.full.pdf }} | ||
</ref> | </ref> | ||
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*CK20 +ve/-ve. | *CK20 +ve/-ve. | ||
*HepPar-1 -ve. | *HepPar-1 -ve. | ||
*AFP -ve.<ref>STC. 6 December 2010.</ref> | *AFP -ve.<ref name=stc6dec2010>STC. 6 December 2010.</ref> | ||
ICC vs. HCC:<ref name=pmid19173916>[Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.</ref> | ICC vs. HCC:<ref name=pmid19173916>[Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.</ref> | ||