Difference between revisions of "Small cell carcinoma"
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*[[GU pathology|Genitourinary]]. | *[[GU pathology|Genitourinary]]. | ||
**[[Small cell carcinoma of the prostate gland]] - most common small cell carcinoma outside of the lung.<ref name=pmid22110988>{{Cite journal | last1 = Furtado | first1 = P. | last2 = Lima | first2 = MV. | last3 = Nogueira | first3 = C. | last4 = Franco | first4 = M. | last5 = Tavora | first5 = F. | title = Review of small cell carcinomas of the prostate. | journal = Prostate Cancer | volume = 2011 | issue = | pages = 543272 | month = | year = 2011 | doi = 10.1155/2011/543272 | PMID = 22110988 }}</ref> | **[[Small cell carcinoma of the prostate gland]] - most common small cell carcinoma outside of the lung.<ref name=pmid22110988>{{Cite journal | last1 = Furtado | first1 = P. | last2 = Lima | first2 = MV. | last3 = Nogueira | first3 = C. | last4 = Franco | first4 = M. | last5 = Tavora | first5 = F. | title = Review of small cell carcinomas of the prostate. | journal = Prostate Cancer | volume = 2011 | issue = | pages = 543272 | month = | year = 2011 | doi = 10.1155/2011/543272 | PMID = 22110988 }}</ref> | ||
**[[Small cell carcinoma of the urinary bladder]]. | |||
**[[Ovarian small cell carcinoma of the hypercalcemic type]]. | **[[Ovarian small cell carcinoma of the hypercalcemic type]]. | ||
*[[Head & neck pathology|Head & neck]]. | *[[Head & neck pathology|Head & neck]]. | ||
Revision as of 03:11, 6 January 2014
Small cell carcinoma is a type of carcinoma. It is mostly commonly from the lung; 95% of cases are from the lung.[1]
It may be abbreviated SCC, leading to confusion with squamous cell carcinoma.
Overview
Grouping
May be grouped as:[1]
- Pulmonary.
- Gastrointestinal.
- Genitourinary.
- Small cell carcinoma of the prostate gland - most common small cell carcinoma outside of the lung.[2]
- Small cell carcinoma of the urinary bladder.
- Ovarian small cell carcinoma of the hypercalcemic type.
- Head & neck.
- Breast.
- Other.
Sites other than lung
General
Classic tumour with paraneoplastic syndromes - may be associated with:[5]
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
- Clinical: hyponatremia.
- Paraneoplastic cerebellar degeneration.
- Lambert-Eaton myasthenic syndrome.
Microscopic
Features:
- Small cells -- typically 15-20 micrometers ~ 2x the size of RBC.
- Scant cytoplasm.
- Stippled chromatin +/- smudging of the chromatin.
- +/-Nuclear moulding.
DDx:
Images
www:
Small cell carcinoma - cytology (WC)
Metastatic small cell carcinoma - high mag. (WC)
Metastatic small cell carcinoma - very high mag. (WC)
Special types
See also
- Lung tumours.
- Azzopardi phenomenon.
- Chloroma (AKA granulocytic sarcoma, myeloid sarcoma).
- Neuroendocrine tumours.
References
- ↑ 1.0 1.1 Grossman, RA.; Pedroso, FE.; Byrne, MM.; Koniaris, LG.; Misra, S. (May 2011). "Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?". J Surg Oncol. doi:10.1002/jso.21976. PMID 21618245.
- ↑ Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
- ↑ Cesaretti, M.; Guarnieri, A.; Gaggelli, I.; Tirone, A.; Francioli, N.; Carli, AF.. "Small cell carcinoma of the breast. Report of a case.". Ann Ital Chir 82 (1): 61-4. PMID 21657157.
- ↑ Beach, DF.; Klump, WJ.; Haddad, G.; Reid, LM.; Schwarting, R.; Hageboutros, A. (Jun 2011). "Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland.". Med Oncol. doi:10.1007/s12032-011-9996-7. PMID 21644012.
- ↑ Sher, T.; Dy, GK.; Adjei, AA. (Mar 2008). "Small cell lung cancer.". Mayo Clin Proc 83 (3): 355-67. PMID 18316005.