Small cell carcinoma of the urinary bladder

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Small cell carcinoma of the urinary bladder
Diagnosis in short

Small cell carcinoma of the urinary bladder. H&E stain.
LM DDx small cell carcinoma of the prostate gland, lymphoma (large cell), other small round blue cell tumours
Stains pankeratin +ve, chromogranin +ve, synaptophysin +ve, CD56 +ve
Site urinary bladder

Symptoms +/-hematuria
Prevalence very rare
Prognosis poor
Clin. DDx other bladder tumours esp. urothelial carcinoma

Small cell carcinoma of the urinary bladder, abbreviated SCCUB, is a rare malignant neoplasm of the urinary bladder.

General

  • Very rare[1] - less than 1% of bladder cancers in one series.[2]
  • Poor prognosis[1] - survival ~ 11 months.[2]

Clinical:

  • Hematuria - typical presentation.[2]

Epidemiology:

Microscopic

Features:

Note:

DDx:

Images

IHC

See also

References

  1. 1.0 1.1 Koga, F.; Yokoyama, M.; Fukushima, H. (Nov 2013). "Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments.". Expert Rev Anticancer Ther 13 (11): 1269-79. doi:10.1586/14737140.2013.851605. PMID 24168010.
  2. 2.0 2.1 2.2 2.3 2.4 Hou, CP.; Lin, YH.; Chen, CL.; Chang, PL.; Tsui, KH. (2013). "Clinical outcome of primary small cell carcinoma of the urinary bladder.". Onco Targets Ther 6: 1179-85. doi:10.2147/OTT.S49879. PMID 24009428.