Difference between revisions of "Neuropathology"

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===Electron microscopy===
===Electron microscopy===
*Granular osmiophilic material (GOM).
*Granular osmiophilic material (GOM).


==Progressive multifocal leukoencephalopathy==
==Progressive multifocal leukoencephalopathy==
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*Caused by ''JC virus'' (a type of [[polyomavirus]]<ref name=pmid21499097>{{Cite journal  | last1 = Berger | first1 = JR. | title = The basis for modeling progressive multifocal leukoencephalopathy pathogenesis. | journal = Curr Opin Neurol | volume = 24 | issue = 3 | pages = 262-7 | month = Jun | year = 2011 | doi = 10.1097/WCO.0b013e328346d2a3 | PMID = 21499097 }}</ref>) in the context of immunodeficiency; usu. in the setting of [[HIV]] infection.<ref name=pmid12709870>{{Cite journal  | last1 = Berger | first1 = JR. | title = Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. | journal = J Neurovirol | volume = 9 Suppl 1 | issue =  | pages = 38-41 | month =  | year = 2003 | doi = 10.1080/13550280390195261 | PMID = 12709870 }}</ref>
*Caused by ''JC virus'' (a type of [[polyomavirus]]<ref name=pmid21499097>{{Cite journal  | last1 = Berger | first1 = JR. | title = The basis for modeling progressive multifocal leukoencephalopathy pathogenesis. | journal = Curr Opin Neurol | volume = 24 | issue = 3 | pages = 262-7 | month = Jun | year = 2011 | doi = 10.1097/WCO.0b013e328346d2a3 | PMID = 21499097 }}</ref>) in the context of immunodeficiency; usu. in the setting of [[HIV]] infection.<ref name=pmid12709870>{{Cite journal  | last1 = Berger | first1 = JR. | title = Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. | journal = J Neurovirol | volume = 9 Suppl 1 | issue =  | pages = 38-41 | month =  | year = 2003 | doi = 10.1080/13550280390195261 | PMID = 12709870 }}</ref>
**Approximately 5% of HIV patients develop PML.<ref name=pmid12709870/>
**Approximately 5% of HIV patients develop PML.<ref name=pmid12709870/>


===Microscopic===
===Microscopic===
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