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Difference between revisions of "Invasive breast cancer"
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→Glycogen-rich clear cell carcinoma of the breast: more
(→Adenoid cystic carcinoma of the breast: +glycogen-rich clear cell carcinoma) |
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*Possibly a variant of [[apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi = | PMID = 7611537 }} | *Possibly a variant of [[apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi = | PMID = 7611537 }} | ||
</ref> | </ref> | ||
*Prognosis usu. poor. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.<ref name=pmid20551566>{{Cite journal | last1 = Thondavadi | first1 = SR. | last2 = Krishnamurthy | first2 = J. | last3 = Gubbanna | first3 = VM. | title = A case report of glycogen-rich clear cell carcinoma of breast. | journal = Indian J Pathol Microbiol | volume = 53 | issue = 2 | pages = 374-5 | month = | year = | doi = 10.4103/0377-4929.64289 | PMID = 20551566 | URL = http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=2;spage=374;epage=375;aulast=Thondavadi }}</ref> | *Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.<ref name=pmid20551566>{{Cite journal | last1 = Thondavadi | first1 = SR. | last2 = Krishnamurthy | first2 = J. | last3 = Gubbanna | first3 = VM. | title = A case report of glycogen-rich clear cell carcinoma of breast. | journal = Indian J Pathol Microbiol | volume = 53 | issue = 2 | pages = 374-5 | month = | year = | doi = 10.4103/0377-4929.64289 | PMID = 20551566 | URL = http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=2;spage=374;epage=375;aulast=Thondavadi }}</ref> | ||
** | **Various architectural arrangements: cords, trabeculae, clusters, cribriform. | ||
**Minimal nuclear pleomorphism. | **Minimal nuclear pleomorphism. | ||
Notes: | Notes: | ||
*Histologic appearance similar to ''[[hyalinizing clear cell carcinoma]]''. | *Histologic appearance may be similar to ''[[hyalinizing clear cell carcinoma]]''. | ||
DDx: | DDx: | ||
| Line 504: | Line 504: | ||
*Apocrine carcinoma. | *Apocrine carcinoma. | ||
*Secretory carcinoma. | *Secretory carcinoma. | ||
Image: | |||
*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2010_53_2_374_64289_f1.jpg GRCC (ijpmonline.org)].<ref name=pmid20551566/> | |||
===Stains=== | ===Stains=== | ||
| Line 513: | Line 516: | ||
*Oil red O -ve. | *Oil red O -ve. | ||
**Lipid-rich carcinoma +ve. | **Lipid-rich carcinoma +ve. | ||
===IHC=== | ===IHC=== | ||
Features:<ref name=pmid20551566/> | Features:<ref name=pmid20551566/> | ||