Difference between revisions of "Sertoli cell nodule"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sertoli_cell_nodule_high_mag.jpg | |||
| Width = | |||
| Caption = Sertoli cell nodule. [[H&E stain]]. | |||
| Synonyms = Pick's adenoma, testicular [[tubular adenoma]], tubular adenoma of the testis | |||
| Micro = unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a [[tubular adenoma of the gastrointestinal tract]]) | |||
| Subtypes = | |||
| LMDDx = [[Sertoli cell tumour]], [[sex cord tumour with annular tubules]], [[gonadoblastoma]] | |||
| Stains = | |||
| IHC = alpha-inhibin +ve, PLAP -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[testis]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-undescended testis | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon in general | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental. | |||
It is also known as '''Pick's adenoma''', '''testicular tubular adenoma''' and '''tubular adenoma of the testis'''. | |||
==General== | |||
*Benign proliferation of Sertoli cells - associated with [[cryptorchidism]] (undescended testis). | |||
*Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH|227}}</ref> | |||
==Gross== | |||
*Usually an incidental finding, rarely presents as a testicular mass.<ref name=pmid21107095>{{Cite journal | last1 = Vallangeon | first1 = BD. | last2 = Eble | first2 = JN. | last3 = Ulbright | first3 = TM. | title = Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses. | journal = Am J Surg Pathol | volume = 34 | issue = 12 | pages = 1874-80 | month = Dec | year = 2010 | doi = 10.1097/PAS.0b013e3181fcab70 | PMID = 21107095 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_DCHH227>{{Ref DCHH|227}}</ref><ref>{{cite journal |author=Ricco R, Bufo P |title=[Histologic study of 3 cases of so-called tubular adenoma of the testis] |language=Italian |journal=Boll. Soc. Ital. Biol. Sper. |volume=56 |issue=20 |pages=2110–5 |year=1980 |month=October |pmid=6109541 |doi= |url=}}</ref> | |||
*Unencapsulated nodules composed of well-formed tubules. | |||
**May contain eosinophilic (hyaline) blob in lumen (centre). | |||
*Cells - vaguely resemble immature Sertoli cells: | |||
**Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a [[tubular adenoma of the gastrointestinal tract]] - '''key feature'''. | |||
DDx:<ref name=pmid21107095/> | |||
*[[Sertoli cell tumour]]. | |||
*[[Sex cord tumour with annular tubules]]. | |||
*[[Gonadoblastoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Sertoli_cell_nodule_high_mag.jpg | Sertoli cell nodule - high mag. (WC) | |||
Image:Sertoli_cell_nodule_low_mag.jpg | Sertoli cell nodule - low mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid21107095/> | |||
*Alpha-inhibin +ve (5/5 cases). | |||
*OCT3/4 -ve (5/5 cases). | |||
Other: | |||
*[[PLAP]] -ve. | |||
==Sign out== | |||
<pre> | |||
TESTICLE, LEFT, ORCHIECTOMY: | |||
- ATROPHIC TESTICLE WITH SERTOLI CELL NODULES. | |||
- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA). | |||
- NEGATIVE FOR MALIGNANCY. | |||
COMMENT: | |||
The above findings are supported by immunostains. The tubules stain with alpha-inhibin and | |||
are negative for PLAP. | |||
</pre> | |||
==See also== | |||
*[[Testis]]. | |||
*[[Sertoli cell tumour]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Testis]] | |||
[[Category:Diagnosis]] | |||
Latest revision as of 23:56, 15 March 2016
| Sertoli cell nodule | |
|---|---|
| Diagnosis in short | |
 Sertoli cell nodule. H&E stain. | |
|
| |
| Synonyms | Pick's adenoma, testicular tubular adenoma, tubular adenoma of the testis |
|
| |
| LM | unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a tubular adenoma of the gastrointestinal tract) |
| LM DDx | Sertoli cell tumour, sex cord tumour with annular tubules, gonadoblastoma |
| IHC | alpha-inhibin +ve, PLAP -ve |
| Site | testis |
|
| |
| Clinical history | +/-undescended testis |
| Prevalence | uncommon in general |
Sertoli cell nodule, abbreviated SCN, is a benign lesion of the testis that is usually incidental.
It is also known as Pick's adenoma, testicular tubular adenoma and tubular adenoma of the testis.
General
- Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis).
- Not composed of a clonal cell population, i.e. not neoplastic; thus, technically, should not be called an adenoma.[1]
Gross
- Usually an incidental finding, rarely presents as a testicular mass.[2]
Microscopic
- Unencapsulated nodules composed of well-formed tubules.
- May contain eosinophilic (hyaline) blob in lumen (centre).
- Cells - vaguely resemble immature Sertoli cells:
- Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a tubular adenoma of the gastrointestinal tract - key feature.
DDx:[2]
Images
Sertoli cell nodule - high mag. (WC)
Sertoli cell nodule - low mag. (WC)
IHC
Features:[2]
- Alpha-inhibin +ve (5/5 cases).
- OCT3/4 -ve (5/5 cases).
Other:
- PLAP -ve.
Sign out
TESTICLE, LEFT, ORCHIECTOMY: - ATROPHIC TESTICLE WITH SERTOLI CELL NODULES. - NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA). - NEGATIVE FOR MALIGNANCY. COMMENT: The above findings are supported by immunostains. The tubules stain with alpha-inhibin and are negative for PLAP.
See also
References
- ↑ 1.0 1.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 227. ISBN 978-0470519035.
- ↑ 2.0 2.1 2.2 Vallangeon, BD.; Eble, JN.; Ulbright, TM. (Dec 2010). "Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses.". Am J Surg Pathol 34 (12): 1874-80. doi:10.1097/PAS.0b013e3181fcab70. PMID 21107095.
- ↑ Ricco R, Bufo P (October 1980). "[Histologic study of 3 cases of so-called tubular adenoma of the testis]" (in Italian). Boll. Soc. Ital. Biol. Sper. 56 (20): 2110–5. PMID 6109541.