Difference between revisions of "Tumour budding"
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[[Image:Tumour budding in colorectal carcinoma - high mag.jpg|thumb|Tumour budding in [[colorectal carcinoma]]. [[H&E stain]]. (WC/Nephron)]] | |||
'''Tumour budding''' refers to lone tumour cells ''or'' small clusters of tumour cells at the advancing front of a tumour.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | '''Tumour budding''' refers to lone tumour cells ''or'' small clusters of tumour cells at the advancing front of a tumour.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | ||
==General== | |||
*Poor prognosticator in colorectal carcinoma,<ref name=pmid22790014>{{Cite journal | last1 = Mitrovic | first1 = B. | last2 = Schaeffer | first2 = DF. | last3 = Riddell | first3 = RH. | last4 = Kirsch | first4 = R. | title = Tumor budding in colorectal carcinoma: time to take notice. | journal = Mod Pathol | volume = 25 | issue = 10 | pages = 1315-25 | month = Oct | year = 2012 | doi = 10.1038/modpathol.2012.94 | PMID = 22790014 }}</ref> and [[invasive ductal carcinoma of the breast]].<ref name=pmid26263482>{{Cite journal | last1 = Gujam | first1 = FJ. | last2 = McMillan | first2 = DC. | last3 = Mohammed | first3 = ZM. | last4 = Edwards | first4 = J. | last5 = Going | first5 = JJ. | title = The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer. | journal = Br J Cancer | volume = 113 | issue = 7 | pages = 1066-74 | month = Sep | year = 2015 | doi = 10.1038/bjc.2015.287 | PMID = 26263482 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Definition in rectal carcinoma - based on international consensus:<ref name=pmid28548122>{{Cite journal | last1 = Lugli | first1 = A. | last2 = Kirsch | first2 = R. | last3 = Ajioka | first3 = Y. | last4 = Bosman | first4 = F. | last5 = Cathomas | first5 = G. | last6 = Dawson | first6 = H. | last7 = El Zimaity | first7 = H. | last8 = Fléjou | first8 = JF. | last9 = Hansen | first9 = TP. | title = Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. | journal = Mod Pathol | volume = 30 | issue = 9 | pages = 1299-1311 | month = Sep | year = 2017 | doi = 10.1038/modpathol.2017.46 | PMID = 28548122 }}</ref> | |||
*Tumour bud = 1-4 cell(s) -- at the tumour front. | *Tumour bud = 1-4 cell(s) -- at the tumour front. | ||
* | |||
Grading: | |||
*Low grade: 0-4 tumour buds. | |||
*Intermediate grade: 5-9 tumour buds. | |||
*High grade: >=10 tumour buds. | |||
Note: | Note: | ||
* | *Assessed in a field area of 0.785 mm<sup>2</sup>.<ref name=pmid28548122/> | ||
**Microscopes with a 22 mm eye pieces typically have a 0.2376 mm*mm field area with the 40x objective; thus, three fields is 0.7128 mm*mm. | |||
** | **Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | ||
*"Tumour buds suspended in pools of mucin should not be counted" as per the consensus.<ref name=pmid28548122/> | |||
DDx: | DDx: | ||
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Image: Tumour budding in colorectal carcinoma - very high mag.jpg | Tumour budding in CRC - very high mag. (WC) | Image: Tumour budding in colorectal carcinoma - very high mag.jpg | Tumour budding in CRC - very high mag. (WC) | ||
</gallery> | </gallery> | ||
== Sign out == | |||
<pre> | |||
There are <5 tumour buds/0.785 mm*mm; this tumour has low grade tumour budding. | |||
</pre> | |||
<pre> | |||
There are 5-9 tumour buds/0.785 mm*mm; this tumour has intermediate grade tumour budding. | |||
</pre> | |||
<pre> | |||
There are >=10 tumour buds/0.785 mm*mm; this tumour has high grade tumour budding. | |||
</pre> | |||
===Alternate=== | |||
<pre> | |||
The tumour is NEGATIVE for significant tumour budding (<5 buds/0.785 mm*mm). | |||
</pre> | |||
==See also== | ==See also== | ||
| Line 25: | Line 49: | ||
*[[In-transit metastasis]]. | *[[In-transit metastasis]]. | ||
*[[Tumour deposits]]. | *[[Tumour deposits]]. | ||
*[[Worst pattern of invasion]]. | |||
*[[Spread through air spaces]]. | |||
==References== | ==References== | ||
Latest revision as of 15:50, 25 August 2023
Tumour budding refers to lone tumour cells or small clusters of tumour cells at the advancing front of a tumour.[1]
General
- Poor prognosticator in colorectal carcinoma,[2] and invasive ductal carcinoma of the breast.[3]
Microscopic
Definition in rectal carcinoma - based on international consensus:[4]
- Tumour bud = 1-4 cell(s) -- at the tumour front.
Grading:
- Low grade: 0-4 tumour buds.
- Intermediate grade: 5-9 tumour buds.
- High grade: >=10 tumour buds.
Note:
- Assessed in a field area of 0.785 mm2.[4]
- Microscopes with a 22 mm eye pieces typically have a 0.2376 mm*mm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.
- Tumour budding was previously assessed in a field of 0.385 mm2.[1]
- "Tumour buds suspended in pools of mucin should not be counted" as per the consensus.[4]
DDx:
- Poorly differentiated adenocarcinoma.
Images
Tumour budding in CRC - intermed. mag. (WC)
Tumour budding in CRC - high mag. (WC)
Tumour budding in CRC - very high mag. (WC)
Sign out
There are <5 tumour buds/0.785 mm*mm; this tumour has low grade tumour budding.
There are 5-9 tumour buds/0.785 mm*mm; this tumour has intermediate grade tumour budding.
There are >=10 tumour buds/0.785 mm*mm; this tumour has high grade tumour budding.
Alternate
The tumour is NEGATIVE for significant tumour budding (<5 buds/0.785 mm*mm).
See also
- High risk features in colorectal adenomatous polyps.
- In-transit metastasis.
- Tumour deposits.
- Worst pattern of invasion.
- Spread through air spaces.
References
- ↑ 1.0 1.1 Ueno, H.; Murphy, J.; Jass, JR.; Mochizuki, H.; Talbot, IC. (Feb 2002). "Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer.". Histopathology 40 (2): 127-32. PMID 11952856.
- ↑ Mitrovic, B.; Schaeffer, DF.; Riddell, RH.; Kirsch, R. (Oct 2012). "Tumor budding in colorectal carcinoma: time to take notice.". Mod Pathol 25 (10): 1315-25. doi:10.1038/modpathol.2012.94. PMID 22790014.
- ↑ Gujam, FJ.; McMillan, DC.; Mohammed, ZM.; Edwards, J.; Going, JJ. (Sep 2015). "The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer.". Br J Cancer 113 (7): 1066-74. doi:10.1038/bjc.2015.287. PMID 26263482.
- ↑ 4.0 4.1 4.2 Lugli, A.; Kirsch, R.; Ajioka, Y.; Bosman, F.; Cathomas, G.; Dawson, H.; El Zimaity, H.; Fléjou, JF. et al. (Sep 2017). "Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.". Mod Pathol 30 (9): 1299-1311. doi:10.1038/modpathol.2017.46. PMID 28548122.