Difference between revisions of "Juvenile polyp"

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#redirect [[Gastrointestinal_tract_polyps#Juvenile_polyp]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Gastric_juvenile_polyp_-_very_low_mag.jpg
| Width      =
| Caption    = Juvenile polyp (stomach). [[H&E stain]].
| Micro      = eroded, smooth or lobulated surface, pedunculated, increased lamina propria (LP) +/- edema,
cystically dilated gland, +/-inflammation
| Subtypes  =
| LMDDx      = [[inflammatory polyp]], [[hyperplastic polyp of the stomach]], [[Cronkhite-Canada syndrome]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[gastrointestinal tract polyps]]
| Assdx      =
| Syndromes  = [[Juvenile polyposis syndrome]]
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign itself; multiple = marker of increased risk of malignancy
| Other      =
| ClinDDx    = other [[GI polyps]]
}}
'''Juvenile polyp''', abbreviated '''JP''', is a type of [[hamartoma|hamartomatous]][[Gastrointestinal tract polyps|gastrointestinal polyp]].
 
In adults, it is known as a '''retention polyp'''.
 
==General==
*Uncommon.
 
May be part of a syndrome:
*[[Juvenile polyposis syndrome]] (JPS) - see JPS article for criteria.
*[[Cronkhite-Canada syndrome]].
*[[Cowden syndrome]].
 
==Gross==
*Mushroom-like shape.
 
==Microscopic==
Features:<ref name=Ref_PBoD859>{{Ref PBoD|859}}</ref><ref name=pmid12692201>{{Cite journal  | last1 = Bronner | first1 = MP. | title = Gastrointestinal inherited polyposis syndromes. | journal = Mod Pathol | volume = 16 | issue = 4 | pages = 359-65 | month = Apr | year = 2003 | doi = 10.1097/01.MP.0000062992.54036.E4 | PMID = 12692201 | url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>
*Eroded, smooth or lobulated surface.
*Pedunculated.
*Increased lamina propria (LP) +/- edema.
*Cystically dilated gland.
*Often inflammed.
 
Mnemonic ''DIES'' = dilated glands, increased LP & inflammation of the LP, eroded/smooth surface, stalk.
 
Notes:
*May have nuclear changes like those seen in adenomatous polyps.
 
DDx:
*[[Inflammatory polyp]].
*[[Hyperplastic polyp of the stomach]] - less lamina propria, foveolar hyperplasia (long tortuous glands).
*[[Cronkhite-Canada syndrome]] - have changes in the surrounding mucosa, clinical findings (nail atrophy, skin pigment, alopecia).
 
===Images===
<gallery>
Image:Gastric_juvenile_polyp_-_very_low_mag.jpg | Juvenile polyp of the stomach - very low mag. (WC/Nephron)
Image:Gastric_juvenile_polyp_-_2_-_very_low_mag.jpg | Juvenile polyp of the stomach - very low mag. (WC/Nephron)
</gallery>
 
==IHC==
*Usually none.
 
Notes:
*IHC can be used if it is suspected to have dysplasia (p53, Ki-67).
**p53 mutations in dysplastic epithelium -- negative stain (normal).
 
==Sign out==
<pre>
Polyp, Sigmoid Colon, Polypectomy:
- Juvenile polyp/retention polyp.
</pre>
 
===Block letters===
<pre>
RECTOSIGMOID POLYP, BIOPSY:
- RETENTION POLYP.
</pre>
 
==See also==
*[[Gastrointestinal tract polyps]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Gastrointestinal pathology]]

Latest revision as of 21:11, 8 April 2018

Juvenile polyp
Diagnosis in short

Juvenile polyp (stomach). H&E stain.
LM

eroded, smooth or lobulated surface, pedunculated, increased lamina propria (LP) +/- edema,

cystically dilated gland, +/-inflammation
LM DDx inflammatory polyp, hyperplastic polyp of the stomach, Cronkhite-Canada syndrome
Site gastrointestinal tract polyps
Syndromes Juvenile polyposis syndrome
Prevalence uncommon
Prognosis benign itself; multiple = marker of increased risk of malignancy
Clin. DDx other GI polyps

Juvenile polyp, abbreviated JP, is a type of hamartomatousgastrointestinal polyp.

In adults, it is known as a retention polyp.

General

  • Uncommon.

May be part of a syndrome:

Gross

  • Mushroom-like shape.

Microscopic

Features:[1][2]

  • Eroded, smooth or lobulated surface.
  • Pedunculated.
  • Increased lamina propria (LP) +/- edema.
  • Cystically dilated gland.
  • Often inflammed.

Mnemonic DIES = dilated glands, increased LP & inflammation of the LP, eroded/smooth surface, stalk.

Notes:

  • May have nuclear changes like those seen in adenomatous polyps.

DDx:

Images

  • Juvenile polyp of the stomach - very low mag. (WC/Nephron)

  • Juvenile polyp of the stomach - very low mag. (WC/Nephron)

IHC

  • Usually none.

Notes:

  • IHC can be used if it is suspected to have dysplasia (p53, Ki-67).
    • p53 mutations in dysplastic epithelium -- negative stain (normal).

Sign out

Polyp, Sigmoid Colon, Polypectomy:
- Juvenile polyp/retention polyp.

Block letters

RECTOSIGMOID POLYP, BIOPSY: 
- RETENTION POLYP.

See also

References

  1. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 859. ISBN 0-7216-0187-1.
  2. ↑ Bronner, MP. (Apr 2003). "Gastrointestinal inherited polyposis syndromes.". Mod Pathol 16 (4): 359-65. doi:10.1097/01.MP.0000062992.54036.E4. PMID 12692201. http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html.
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