Difference between revisions of "Sex cord tumour with annular tubules"
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| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Sex_cord_tumour_with_annular_tubules_-_2_-_very_high_mag.jpg | | Image = Sex_cord_tumour_with_annular_tubules_-_2_-_very_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = SCTAT. [[H&E stain]]. | | Caption = SCTAT. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material | | Micro = well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material | ||
| Subtypes = benign, malignant (very rare) | | Subtypes = benign, malignant (very rare) | ||
| LMDDx = [[Sertoli-Leydig tumour]], [[granulosa cell tumour]], [[Brenner tumour]] | | LMDDx = [[Sertoli-Leydig tumour]], [[granulosa cell tumour]], [[Brenner tumour]], [[gonadoblastoma]], [[neuroendocrine tumour]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = inhibin +ve, [[calretinin]] +ve, pankeratin +ve, [[EMA]] -ve, WT-1 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Sex cord tumour with annular tubules''', abbreviated '''SCTAT''', is an uncommon sex cord tumour. | '''Sex cord tumour with annular tubules''', abbreviated '''SCTAT''', is an uncommon [[Sex cord-stromal tumours|sex cord tumour]]. | ||
It is '''not''' ''sex cord tumour with angulated tubules''. | It is '''not''' ''sex cord tumour with angulated tubules''. | ||
| Line 55: | Line 55: | ||
*[[Granulosa cell tumour]] - have Call-Exner bodies, which don't have a well-defined/solid content. | *[[Granulosa cell tumour]] - have Call-Exner bodies, which don't have a well-defined/solid content. | ||
*[[Brenner tumour]] - [[coffee-bean nuclei]]. | *[[Brenner tumour]] - [[coffee-bean nuclei]]. | ||
*[[Neuroendocrine tumour]]. | |||
*[[Gonadoblastoma]]. | |||
===Images=== | ===Images=== | ||
| Line 69: | Line 71: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid19703688>{{Cite journal | last1 = Nosov | first1 = V. | last2 = Park | first2 = S. | last3 = Rao | first3 = J. | last4 = Memarzadeh | first4 = S. | title = Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. | journal = Fertil Steril | volume = 92 | issue = 4 | pages = 1497.e5-8 | month = Oct | year = 2009 | doi = 10.1016/j.fertnstert.2009.07.1002 | PMID = 19703688 }}</ref> | Features:<ref name=pmid19703688>{{Cite journal | last1 = Nosov | first1 = V. | last2 = Park | first2 = S. | last3 = Rao | first3 = J. | last4 = Memarzadeh | first4 = S. | title = Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. | journal = Fertil Steril | volume = 92 | issue = 4 | pages = 1497.e5-8 | month = Oct | year = 2009 | doi = 10.1016/j.fertnstert.2009.07.1002 | PMID = 19703688 }}</ref> | ||
*Inhibin +ve | *Inhibin +ve<ref>{{Cite journal | last1 = Guerrieri | first1 = C. | last2 = Frånlund | first2 = B. | last3 = Malmström | first3 = H. | last4 = Boeryd | first4 = B. | title = Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. | journal = Int J Gynecol Pathol | volume = 17 | issue = 3 | pages = 266-71 | month = Jul | year = 1998 | doi = | PMID = 9656124 }}</ref> (3/3<ref name=pmid12808064/>). | ||
*Calretinin +ve. | *Calretinin +ve (3/3<ref name=pmid12808064/>). | ||
*CD99 +ve. | *CD99 +ve. | ||
*Pankeratin +ve. | *Pankeratin +ve. | ||
| Line 77: | Line 79: | ||
Others: | Others: | ||
*S-100 -ve. | *S-100 -ve. | ||
*AFP -ve. | *[[AFP]] -ve. | ||
*CD10 -ve. | *CD10 -ve.<ref name=pmid17885484>{{cite journal |author=Oliva E, Garcia-Miralles N, Vu Q, Young RH |title=CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases |journal=Int. J. Gynecol. Pathol. |volume=26 |issue=4 |pages=359–67 |year=2007 |month=October |pmid=17885484 |doi=10.1097/PGP.0b013e318064511c |url=}}</ref> | ||
*[[EMA]] -ve (0/3<ref name=pmid12808064>{{Cite journal | last1 = Deavers | first1 = MT. | last2 = Malpica | first2 = A. | last3 = Liu | first3 = J. | last4 = Broaddus | first4 = R. | last5 = Silva | first5 = EG. | title = Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin. | journal = Mod Pathol | volume = 16 | issue = 6 | pages = 584-90 | month = Jun | year = 2003 | doi = 10.1097/01.MP.0000073133.79591.A1 | PMID = 12808064 }}</ref>). | |||
*WT1 +ve (3/3<ref name=pmid12808064/>). | |||
==See also== | ==See also== | ||
*[[Ovarian tumours]]. | *[[Ovarian tumours]]. | ||
*[[Sex cord-stromal tumours]]. | |||
==References== | ==References== | ||
Latest revision as of 14:23, 12 May 2016
Sex cord tumour with annular tubules, abbreviated SCTAT, is an uncommon sex cord tumour.
| Sex cord tumour with annular tubules | |
|---|---|
| Diagnosis in short | |
 SCTAT. H&E stain. | |
|
| |
| LM | well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material |
| Subtypes | benign, malignant (very rare) |
| LM DDx | Sertoli-Leydig tumour, granulosa cell tumour, Brenner tumour, gonadoblastoma, neuroendocrine tumour |
| IHC | inhibin +ve, calretinin +ve, pankeratin +ve, EMA -ve, WT-1 +ve |
| Site | ovary - see ovarian tumours |
|
| |
| Syndromes | Peutz-Jeghers syndrome |
|
| |
| Prevalence | uncommon |
| Prognosis | usually good (benign) |
| Clin. DDx | other ovarian tumours |
It is not sex cord tumour with angulated tubules.
General
- Associated with Peutz-Jeghers syndrome.[1]
- Large tumours more likely sporadic.
- Small tumours more likely Peutz-Jeghers syndrome and incidental.
- Usually benign.
- Malignant cases reported.[2]
Microscopic
Features:
- Well-circumscribed nests of cells with nuclei at the periphery.
- Annular tubules (ring-shaped tubules) with dense hyaline material.
Notes:
- Annular = shape of a ring.[3]
- May focally have features of Sertoli cell tumour or granulosa cell tumour.[4]
DDx:
- Sertoli-Leydig tumour - has double palisading with overlap of the layers.
- Granulosa cell tumour - have Call-Exner bodies, which don't have a well-defined/solid content.
- Brenner tumour - coffee-bean nuclei.
- Neuroendocrine tumour.
- Gonadoblastoma.
Images
www:
SCTAT - intermed. mag. (WC)
SCTAT - high mag. (WC)
SCTAT - very high mag. (WC)
SCTAT - very high mag. (WC)
IHC
Features:[5]
Others:
See also
References
- ↑ Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
- ↑ Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
- ↑ URL: http://dictionary.reference.com/browse/annular. Accessed on: 6 August 2011.
- ↑ Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.
- ↑ Nosov, V.; Park, S.; Rao, J.; Memarzadeh, S. (Oct 2009). "Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report.". Fertil Steril 92 (4): 1497.e5-8. doi:10.1016/j.fertnstert.2009.07.1002. PMID 19703688.
- ↑ Guerrieri, C.; Frånlund, B.; Malmström, H.; Boeryd, B. (Jul 1998). "Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7.". Int J Gynecol Pathol 17 (3): 266-71. PMID 9656124.
- ↑ 7.0 7.1 7.2 7.3 Deavers, MT.; Malpica, A.; Liu, J.; Broaddus, R.; Silva, EG. (Jun 2003). "Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin.". Mod Pathol 16 (6): 584-90. doi:10.1097/01.MP.0000073133.79591.A1. PMID 12808064.
- ↑ Oliva E, Garcia-Miralles N, Vu Q, Young RH (October 2007). "CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases". Int. J. Gynecol. Pathol. 26 (4): 359–67. doi:10.1097/PGP.0b013e318064511c. PMID 17885484.