Difference between revisions of "Sex cord tumour with annular tubules"

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#redirect [[Ovarian_tumours#Sex_cord_tumour_with_annular_tubules]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Sex_cord_tumour_with_annular_tubules_-_2_-_very_high_mag.jpg
| Width      =
| Caption    = SCTAT. [[H&E stain]].
| Synonyms  =
| Micro      = well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material
| Subtypes  = benign, malignant (very rare)
| LMDDx      = [[Sertoli-Leydig tumour]], [[granulosa cell tumour]], [[Brenner tumour]], [[gonadoblastoma]], [[neuroendocrine tumour]]
| Stains    =
| IHC        = inhibin +ve, [[calretinin]] +ve, pankeratin +ve, [[EMA]] -ve, WT-1 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[ovary]] - see ''[[ovarian tumours]]''
| Assdx      =
| Syndromes  = [[Peutz-Jeghers syndrome]]
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usually good (benign)
| Other      =
| ClinDDx    = other [[ovarian tumours]]
| Tx        =
}}
'''Sex cord tumour with annular tubules''', abbreviated '''SCTAT''', is an uncommon [[Sex cord-stromal tumours|sex cord tumour]].


It is '''not''' ''sex cord tumour with angulated tubules''.
==General==
*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid7358344>{{Cite journal  | last1 = Purohit | first1 = RC. | last2 = Alam | first2 = SZ. | title = Sex cord tumour of the ovary with annular tubules (SCTAT). | journal = Histopathology | volume = 4 | issue = 2 | pages = 147-54 | month = Mar | year = 1980 | doi =  | PMID = 7358344 }}</ref>
**Large tumours more likely sporadic.
**Small tumours more likely Peutz-Jeghers syndrome and incidental.
*Usually benign.
**Malignant cases reported.<ref name=pmid10786816>{{Cite journal  | last1 = Lele | first1 = SM. | last2 = Sawh | first2 = RN. | last3 = Zaharopoulos | first3 = P. | last4 = Adesokan | first4 = A. | last5 = Smith | first5 = M. | last6 = Linhart | first6 = JM. | last7 = Arrastia | first7 = CD. | last8 = Krigman | first8 = HR. | title = Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report. | journal = Mod Pathol | volume = 13 | issue = 4 | pages = 466-70 | month = Apr | year = 2000 | doi = 10.1038/modpathol.3880079 | PMID = 10786816 }}</ref>
==Microscopic==
Features:
*Well-circumscribed nests of cells with nuclei at the periphery.
*Annular tubules (ring-shaped tubules) with dense hyaline material.
Notes:
*''Annular'' = shape of a ring.<ref>URL: [http://dictionary.reference.com/browse/annular http://dictionary.reference.com/browse/annular]. Accessed on: 6 August 2011.</ref>
*May focally have features of [[Sertoli cell tumour]] or [[granulosa cell tumour]].<ref name=pmid7104978>{{Cite journal  | last1 = Young | first1 = RH. | last2 = Welch | first2 = WR. | last3 = Dickersin | first3 = GR. | last4 = Scully | first4 = RE. | title = Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix. | journal = Cancer | volume = 50 | issue = 7 | pages = 1384-402 | month = Oct | year = 1982 | doi =  | PMID = 7104978 }}
</ref>
DDx:
*[[Sertoli-Leydig tumour]] - has double palisading with overlap of the layers.
*[[Granulosa cell tumour]] - have Call-Exner bodies, which don't have a well-defined/solid content.
*[[Brenner tumour]] - [[coffee-bean nuclei]].
*[[Neuroendocrine tumour]].
*[[Gonadoblastoma]].
===Images===
www:
*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=10&cat2=120&cat3=1015&cat4=3&stype=n SCTAT - image collection (gfmer.ch)].
*[http://www.pathology.cn/bbs/forum.php?mod=viewthread&tid=57445 Possible SCTAT (pathology.cn)].
<gallery>
Image:Sex_cord_tumour_with_annular_tubules_-_intermed_mag.jpg | SCTAT - intermed. mag. (WC)
Image:Sex_cord_tumour_with_annular_tubules_-_high_mag.jpg | SCTAT - high mag. (WC)
Image:Sex_cord_tumour_with_annular_tubules_-_very_high_mag.jpg | SCTAT - very high mag. (WC)
Image:Sex_cord_tumour_with_annular_tubules_-_2_-_very_high_mag.jpg | SCTAT - very high mag. (WC)
</gallery>
==IHC==
Features:<ref name=pmid19703688>{{Cite journal  | last1 = Nosov | first1 = V. | last2 = Park | first2 = S. | last3 = Rao | first3 = J. | last4 = Memarzadeh | first4 = S. | title = Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. | journal = Fertil Steril | volume = 92 | issue = 4 | pages = 1497.e5-8 | month = Oct | year = 2009 | doi = 10.1016/j.fertnstert.2009.07.1002 | PMID = 19703688 }}</ref>
*Inhibin +ve<ref>{{Cite journal  | last1 = Guerrieri | first1 = C. | last2 = Frånlund | first2 = B. | last3 = Malmström | first3 = H. | last4 = Boeryd | first4 = B. | title = Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. | journal = Int J Gynecol Pathol | volume = 17 | issue = 3 | pages = 266-71 | month = Jul | year = 1998 | doi =  | PMID = 9656124 }}</ref>  (3/3<ref name=pmid12808064/>).
*Calretinin +ve (3/3<ref name=pmid12808064/>).
*CD99 +ve.
*Pankeratin +ve.
*Vimentin +ve.
Others:
*S-100 -ve.
*[[AFP]] -ve.
*CD10 -ve.<ref name=pmid17885484>{{cite journal |author=Oliva E, Garcia-Miralles N, Vu Q, Young RH |title=CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases |journal=Int. J. Gynecol. Pathol. |volume=26 |issue=4 |pages=359–67 |year=2007 |month=October |pmid=17885484 |doi=10.1097/PGP.0b013e318064511c |url=}}</ref>
*[[EMA]] -ve (0/3<ref name=pmid12808064>{{Cite journal  | last1 = Deavers | first1 = MT. | last2 = Malpica | first2 = A. | last3 = Liu | first3 = J. | last4 = Broaddus | first4 = R. | last5 = Silva | first5 = EG. | title = Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin. | journal = Mod Pathol | volume = 16 | issue = 6 | pages = 584-90 | month = Jun | year = 2003 | doi = 10.1097/01.MP.0000073133.79591.A1 | PMID = 12808064 }}</ref>).
*WT1 +ve (3/3<ref name=pmid12808064/>).
==See also==
*[[Ovarian tumours]].
*[[Sex cord-stromal tumours]].
==References==
{{Reflist|2}}
[[Category:Ovarian tumours]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 14:23, 12 May 2016

Sex cord tumour with annular tubules, abbreviated SCTAT, is an uncommon sex cord tumour.

Sex cord tumour with annular tubules
Diagnosis in short

SCTAT. H&E stain.
LM well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material
Subtypes benign, malignant (very rare)
LM DDx Sertoli-Leydig tumour, granulosa cell tumour, Brenner tumour, gonadoblastoma, neuroendocrine tumour
IHC inhibin +ve, calretinin +ve, pankeratin +ve, EMA -ve, WT-1 +ve
Site ovary - see ovarian tumours
Syndromes Peutz-Jeghers syndrome
Prevalence uncommon
Prognosis usually good (benign)
Clin. DDx other ovarian tumours

It is not sex cord tumour with angulated tubules.

General

  • Associated with Peutz-Jeghers syndrome.[1]
    • Large tumours more likely sporadic.
    • Small tumours more likely Peutz-Jeghers syndrome and incidental.
  • Usually benign.
    • Malignant cases reported.[2]

Microscopic

Features:

  • Well-circumscribed nests of cells with nuclei at the periphery.
  • Annular tubules (ring-shaped tubules) with dense hyaline material.

Notes:

DDx:

Images

www:

  • SCTAT - intermed. mag. (WC)

  • SCTAT - high mag. (WC)

  • SCTAT - very high mag. (WC)

  • SCTAT - very high mag. (WC)

IHC

Features:[5]

  • Inhibin +ve[6] (3/3[7]).
  • Calretinin +ve (3/3[7]).
  • CD99 +ve.
  • Pankeratin +ve.
  • Vimentin +ve.

Others:

See also

References

  1. ↑ Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
  2. ↑ Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
  3. ↑ URL: http://dictionary.reference.com/browse/annular. Accessed on: 6 August 2011.
  4. ↑ Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.
  5. ↑ Nosov, V.; Park, S.; Rao, J.; Memarzadeh, S. (Oct 2009). "Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report.". Fertil Steril 92 (4): 1497.e5-8. doi:10.1016/j.fertnstert.2009.07.1002. PMID 19703688.
  6. ↑ Guerrieri, C.; Frånlund, B.; Malmström, H.; Boeryd, B. (Jul 1998). "Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7.". Int J Gynecol Pathol 17 (3): 266-71. PMID 9656124.
  7. ↑ 7.0 7.1 7.2 7.3 Deavers, MT.; Malpica, A.; Liu, J.; Broaddus, R.; Silva, EG. (Jun 2003). "Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin.". Mod Pathol 16 (6): 584-90. doi:10.1097/01.MP.0000073133.79591.A1. PMID 12808064.
  8. ↑ Oliva E, Garcia-Miralles N, Vu Q, Young RH (October 2007). "CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases". Int. J. Gynecol. Pathol. 26 (4): 359–67. doi:10.1097/PGP.0b013e318064511c. PMID 17885484.
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