Difference between revisions of "S-100"
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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
| Image = Mammary_analogue_secretory_carcinoma_(S100immunohistochemstry,_low_power).jpg | |||
| Width = | |||
| Caption = S-100 staining in a [[secretory carcinoma of the salivary gland]]. | |||
| Abbrev = | |||
| Synonyms = | |||
| Similar = | |||
| Clones = | |||
| Use = [[malignant melanoma]], assess [[perineural invasion]], undifferentiated malignancy | |||
| Subspecial = | |||
| Pattern = nucleus and cytoplasm | |||
| Positive = benign: nerves, adipose tissue; tumour/other: [[granular cell tumour]], [[Rosai-Dorfman disease]]; malignant: [[malignant melanoma]], [[clear cell sarcoma]], [[malignant peripheral nerve sheath tumour]] | |||
| Negative = | |||
| Other = | |||
}} | |||
'''S-100''', also '''S100''', is a commonly used [[immunostain]]. It marks nerves. | '''S-100''', also '''S100''', is a commonly used [[immunostain]]. It marks nerves. | ||
<!-- Dabbs' IHC book uses 'S-100' --> | <!-- Dabbs' IHC book uses 'S-100' as opposed to 'S100' --> | ||
==Positive== | ==Positive== | ||
*Nerves. | *Nerves. | ||
*Interdigitating dendritic cells.<ref>{{Cite journal | last1 = Mesquita | first1 = RA. | last2 = de Araújo | first2 = VC. | last3 = Paes | first3 = RA. | last4 = Nunes | first4 = FD. | last5 = de Souza | first5 = SC. | title = Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas. | journal = J Appl Oral Sci | volume = 17 | issue = 3 | pages = 248-53 | month = | year = | doi = | PMID = 19466261 }} | *[[Schwannoma]]. | ||
*Mature adipose tissue. | |||
*Interdigitating dendritic cells.<ref name=pmid19466261>{{Cite journal | last1 = Mesquita | first1 = RA. | last2 = de Araújo | first2 = VC. | last3 = Paes | first3 = RA. | last4 = Nunes | first4 = FD. | last5 = de Souza | first5 = SC. | title = Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas. | journal = J Appl Oral Sci | volume = 17 | issue = 3 | pages = 248-53 | month = | year = | doi = | PMID = 19466261 }} | |||
</ref> | </ref> | ||
*[[Langerhans cell histiocytosis]]. | |||
*[[Rosai-Dorfman disease]]. | |||
*[[Chordoma]] - also keratin positive ([[AE1/AE3]], [[CK19]], [[CAM5.2]]).<ref name=pmid24296480>{{Cite journal | last1 = Shen | first1 = J. | last2 = Shi | first2 = Q. | last3 = Lu | first3 = J. | last4 = Wang | first4 = DL. | last5 = Zou | first5 = TM. | last6 = Yang | first6 = HL. | last7 = Zhu | first7 = GQ. | title = Histological study of chordoma origin from fetal notochordal cell rests. | journal = Spine (Phila Pa 1976) | volume = 38 | issue = 25 | pages = 2165-70 | month = Dec | year = 2013 | doi = 10.1097/BRS.0000000000000010 | PMID = 24296480 }}</ref> | |||
*[[Granular cell tumour]]. | |||
*[[Nodal nevus]]. | |||
===Malignant tumours=== | |||
*[[Malignant melanoma]] - almost 100% [[sensitivity|sensitive]]. | *[[Malignant melanoma]] - almost 100% [[sensitivity|sensitive]]. | ||
*[[Malignant peripheral nerve sheath tumour]]. | |||
*[[Clear cell sarcoma]]. | |||
*[[Mammary analogue secretory carcinoma]]. | |||
==See also== | ==See also== | ||
Latest revision as of 19:29, 11 February 2021
| S-100 | |
|---|---|
| Immunostain in short | |
.jpg) S-100 staining in a secretory carcinoma of the salivary gland. | |
| Use | malignant melanoma, assess perineural invasion, undifferentiated malignancy |
| Normal staining pattern | nucleus and cytoplasm |
| Positive | benign: nerves, adipose tissue; tumour/other: granular cell tumour, Rosai-Dorfman disease; malignant: malignant melanoma, clear cell sarcoma, malignant peripheral nerve sheath tumour |
S-100, also S100, is a commonly used immunostain. It marks nerves.
Positive
- Nerves.
- Schwannoma.
- Mature adipose tissue.
- Interdigitating dendritic cells.[1]
- Langerhans cell histiocytosis.
- Rosai-Dorfman disease.
- Chordoma - also keratin positive (AE1/AE3, CK19, CAM5.2).[2]
- Granular cell tumour.
- Nodal nevus.
Malignant tumours
- Malignant melanoma - almost 100% sensitive.
- Malignant peripheral nerve sheath tumour.
- Clear cell sarcoma.
- Mammary analogue secretory carcinoma.
See also
References
- ↑ Mesquita, RA.; de Araújo, VC.; Paes, RA.; Nunes, FD.; de Souza, SC.. "Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.". J Appl Oral Sci 17 (3): 248-53. PMID 19466261.
- ↑ Shen, J.; Shi, Q.; Lu, J.; Wang, DL.; Zou, TM.; Yang, HL.; Zhu, GQ. (Dec 2013). "Histological study of chordoma origin from fetal notochordal cell rests.". Spine (Phila Pa 1976) 38 (25): 2165-70. doi:10.1097/BRS.0000000000000010. PMID 24296480.