Difference between revisions of "Hyalinizing trabecular tumour"
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'''Hyalinizing trabecular tumour''', abbreviated '''HTT''', is a rare tumour of the [[thyroid gland]]. It is also known as '''hyalinizing trabecular adenoma'''. | |||
==General== | |||
*Considered by some to be a variant of [[papillary thyroid carcinoma]].<ref name=pmid11117782>{{cite journal |author=Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL |title=Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics |journal=Am. J. Surg. Pathol. |volume=24 |issue=12 |pages=1622–6 |year=2000 |month=December |pmid=11117782 |doi= |url=}}</ref> | |||
*Behaviour similar to papillary thyroid carcinoma - indolent. | |||
==Microscopic== | |||
Features: | |||
*Trabecular arrangement of cells. | |||
**May have "curved" trabeculae. | |||
**Well defined cell borders. | |||
*Extracellular space has hyaline material - '''key feature'''. | |||
*Cytoplasm mimics hyaline material in the extracellular space. | |||
DDx: | |||
*[[Papillary thyroid carcinoma]] (if one believes this is a separate entity). | |||
*[[Medullary thyroid carcinoma]] - not trabecular, nuclei not [[PTC]]-like. | |||
*[[Paraganglioma]].<ref>URL: [http://path.upmc.edu/cases/case465/dx.html http://path.upmc.edu/cases/case465/dx.html]. Accessed on: 17 January 2011.</ref> | |||
===Images=== | |||
<gallery> | |||
Image: Hyalinized trabecular tumour - low mag.jpg | HHT - low mag. (WC) | |||
Image: Hyalinized trabecular tumour - intermed mag.jpg | HHT - intermed. mag. (WC) | |||
Image: Hyalinized trabecular tumour - high mag.jpg | HHT - high mag. (WC) | |||
Image: Thyroid gland - high mag.jpg | Thyroid gland - high mag. (WC) | |||
Image: Hyalinized trabecular tumour - 2 - intermed mag.jpg | HHT - intermed. mag. (WC) | |||
Image: Hyalinized trabecular tumour - 2 - high mag.jpg | HHT - high mag. (WC) | |||
Image: Hyalinized trabecular tumour - 3 - intermed mag.jpg | HHT - intermed. mag. (WC) | |||
Image: Hyalinized trabecular tumour - 3 - high mag.jpg | HHT - high mag. (WC) | |||
Image: Hyalinized trabecular tumour - 3 - very high mag.jpg | HHT - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://archive.biomedcentral.com/1742-6413/3/17/figure/F2?highres=y HTT (biomedcentral.com)].<ref name=pmid16867191>{{Cite journal | last1 = Baloch | first1 = ZW. | last2 = Puttaswamy | first2 = K. | last3 = Brose | first3 = M. | last4 = LiVolsi | first4 = VA. | title = Lack of BRAF mutations in hyalinizing trabecular neoplasm. | journal = Cytojournal | volume = 3 | issue = | pages = 17 | month = | year = 2006 | doi = 10.1186/1742-6413-3-17 | PMID = 16867191 }}</ref> | |||
*[http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.article-g01.fs.jpg HTT (ispub.com)].<ref>URL: [http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html]. Accessed on: 1 January 2012.</ref> | |||
==IHC== | |||
*Thyroglobulin +ve. | |||
*NSE +ve. | |||
*Ki-67 - [[Ki-67 membranous pattern|may have membranous pattern]].<ref name=pmid17525638>{{Cite journal | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref> | |||
==Molecular== | |||
*GLIS rearrangement (PAX8-GLIS3, PAX8-GLIS1).<ref name=pmid30648929>{{Cite journal | last1 = Nikiforova | first1 = MN. | last2 = Nikitski | first2 = AV. | last3 = Panebianco | first3 = F. | last4 = Kaya | first4 = C. | last5 = Yip | first5 = L. | last6 = Williams | first6 = M. | last7 = Chiosea | first7 = SI. | last8 = Seethala | first8 = RR. | last9 = Roy | first9 = S. | title = GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. | journal = Thyroid | volume = 29 | issue = 2 | pages = 161-173 | month = Feb | year = 2019 | doi = 10.1089/thy.2018.0791 | PMID = 30648929 }}</ref> | |||
==See also== | |||
*[[Thyroid gland]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Endocrine pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Latest revision as of 02:00, 19 March 2019
Hyalinizing trabecular tumour, abbreviated HTT, is a rare tumour of the thyroid gland. It is also known as hyalinizing trabecular adenoma.
General
- Considered by some to be a variant of papillary thyroid carcinoma.[1]
- Behaviour similar to papillary thyroid carcinoma - indolent.
Microscopic
Features:
- Trabecular arrangement of cells.
- May have "curved" trabeculae.
- Well defined cell borders.
- Extracellular space has hyaline material - key feature.
- Cytoplasm mimics hyaline material in the extracellular space.
DDx:
- Papillary thyroid carcinoma (if one believes this is a separate entity).
- Medullary thyroid carcinoma - not trabecular, nuclei not PTC-like.
- Paraganglioma.[2]
Images
HHT - low mag. (WC)
HHT - intermed. mag. (WC)
HHT - high mag. (WC)
Thyroid gland - high mag. (WC)
HHT - intermed. mag. (WC)
HHT - high mag. (WC)
HHT - intermed. mag. (WC)
HHT - high mag. (WC)
HHT - very high mag. (WC)
www:
IHC
- Thyroglobulin +ve.
- NSE +ve.
- Ki-67 - may have membranous pattern.[5]
Molecular
- GLIS rearrangement (PAX8-GLIS3, PAX8-GLIS1).[6]
See also
References
- ↑ Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL (December 2000). "Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics". Am. J. Surg. Pathol. 24 (12): 1622–6. PMID 11117782.
- ↑ URL: http://path.upmc.edu/cases/case465/dx.html. Accessed on: 17 January 2011.
- ↑ Baloch, ZW.; Puttaswamy, K.; Brose, M.; LiVolsi, VA. (2006). "Lack of BRAF mutations in hyalinizing trabecular neoplasm.". Cytojournal 3: 17. doi:10.1186/1742-6413-3-17. PMID 16867191.
- ↑ URL: http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html. Accessed on: 1 January 2012.
- ↑ Leonardo, E.; Volante, M.; Barbareschi, M.; Cavazza, A.; Dei Tos, AP.; Bussolati, G.; Papotti, M. (Jun 2007). "Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?". Appl Immunohistochem Mol Morphol 15 (2): 220-3. doi:10.1097/01.pai.0000213122.66096.f0. PMID 17525638.
- ↑ Nikiforova, MN.; Nikitski, AV.; Panebianco, F.; Kaya, C.; Yip, L.; Williams, M.; Chiosea, SI.; Seethala, RR. et al. (Feb 2019). "GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland.". Thyroid 29 (2): 161-173. doi:10.1089/thy.2018.0791. PMID 30648929.