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Difference between revisions of "Nuclear pleomorphism"
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'''Nuclear pleomorphism''' is a common finding in malignant lesions. | [[Image:Glioblastoma_with_extreme_nuclear_enlargement_-_very_high_mag.jpg|thumb|350px|Extreme nuclear pleomorphism in a case of [[glioblastoma]].]] | ||
[[Image:Pleomorphic undifferentiated sarcoma - very high mag.jpg|thumb|350px|right|Severe nuclear pleomorphism is a case of [[pleomorphic undifferentiated sarcoma]]. [[H&E stain]].]] | |||
[[Image:Mucinous lung adenocarcinoma and airway - alt -- high mag.jpg|thumb|350px|right|Some forms of cancer have no or minimal nuclear pleomorphism; mucinous [[adenocarcinoma of the lung]] (left of image) looks similar to (benign) gastric foveolar epithelium and in this image is juxtaposed with benign ciliated epithelium (right of image). [[H&E stain]].]] | |||
'''Nuclear pleomorphism''' is a common finding in [[cancer|malignant lesions]]. '''Anisonucleosis''' is often used as a synonym for ''nuclear pleomorphism''; ''iso-'' means ''equal'' or ''identical'',<ref>URL: [http://dictionary.reference.com/browse/iso-?s=ts http://dictionary.reference.com/browse/iso-?s=ts]. Accessed on: 26 September 2013.</ref> and ''an-'' means ''not''.<ref>URL: [http://dictionary.reference.com/browse/an-?s=t http://dictionary.reference.com/browse/an-?s=t]. Accessed on: 26 September 2013.</ref> | |||
==Definition== | |||
Nuclear pleomorphism is the marked variation of:<ref name=pmid21849255>{{Cite journal | last1 = Rashid | first1 = F. | last2 = Ul Haque | first2 = A. | title = Frequencies of different nuclear morphological features in prostate adenocarcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 6 | pages = 414-21 | month = Dec | year = 2011 | doi = 10.1016/j.anndiagpath.2011.06.002 | PMID = 21849255 }}</ref> | |||
#Nuclear size. | #Nuclear size. | ||
#Nuclear shape. | #Nuclear shape. | ||
#Nuclear staining ( | #Nuclear staining (especially with hyperchromasia). | ||
Memory device '''3 S''': '''s'''ize, '''s'''hape, '''s'''taining. | Memory device '''3 S''': '''s'''ize, '''s'''hape, '''s'''taining. | ||
==Images== | |||
<gallery> | <gallery> | ||
Image:Glioblastoma_with_extreme_nuclear_enlargement_-_high_mag.jpg | Marked nuclear pleomorphism - in a case of glioblastoma - high mag. (WC/Nephron) | Image:Glioblastoma_with_extreme_nuclear_enlargement_-_high_mag.jpg | Marked nuclear pleomorphism - in a case of glioblastoma - high mag. (WC/Nephron) | ||
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*[[NC ratio]]. | *[[NC ratio]]. | ||
*[[Pleomorphic tumours]]. | *[[Pleomorphic tumours]]. | ||
*[[Nuclear atypia]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Basics]] | [[Category:Basics]] | ||