Difference between revisions of "Sertoli cell nodule"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sertoli_cell_nodule_high_mag.jpg | |||
| Width = | |||
| Caption = Sertoli cell nodule. [[H&E stain]]. | |||
| Synonyms = Pick's adenoma, testicular [[tubular adenoma]], tubular adenoma of the testis | |||
| Micro = unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a [[tubular adenoma of the gastrointestinal tract]]) | |||
| Subtypes = | |||
| LMDDx = [[Sertoli cell tumour]], [[sex cord tumour with annular tubules]], [[gonadoblastoma]] | |||
| Stains = | |||
| IHC = alpha-inhibin +ve, PLAP -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[testis]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-undescended testis | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon in general | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental. | '''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental. | ||
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==General== | ==General== | ||
*Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis). | *Benign proliferation of Sertoli cells - associated with [[cryptorchidism]] (undescended testis). | ||
*Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH|227}}</ref> | *Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH|227}}</ref> | ||
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**May contain eosinophilic (hyaline) blob in lumen (centre). | **May contain eosinophilic (hyaline) blob in lumen (centre). | ||
*Cells - vaguely resemble immature Sertoli cells: | *Cells - vaguely resemble immature Sertoli cells: | ||
**Bland hyperchromatic oval/round nuclei that are stratified. | **Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a [[tubular adenoma of the gastrointestinal tract]] - '''key feature'''. | ||
DDx:<ref name=pmid21107095/> | DDx:<ref name=pmid21107095/> | ||
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Image:Sertoli_cell_nodule_low_mag.jpg | Sertoli cell nodule - low mag. (WC) | Image:Sertoli_cell_nodule_low_mag.jpg | Sertoli cell nodule - low mag. (WC) | ||
</gallery> | </gallery> | ||
==IHC== | |||
Features:<ref name=pmid21107095/> | Features:<ref name=pmid21107095/> | ||
*Alpha-inhibin +ve (5/5 cases). | *Alpha-inhibin +ve (5/5 cases). | ||
| Line 33: | Line 64: | ||
Other: | Other: | ||
*PLAP -ve. | *[[PLAP]] -ve. | ||
==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
TESTICLE, LEFT, ORCHIECTOMY: | TESTICLE, LEFT, ORCHIECTOMY: | ||
- ATROPHIC TESTICLE | - ATROPHIC TESTICLE WITH SERTOLI CELL NODULES. | ||
- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA). | |||
- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA. | |||
- NEGATIVE FOR MALIGNANCY. | - NEGATIVE FOR MALIGNANCY. | ||
Latest revision as of 23:56, 15 March 2016
| Sertoli cell nodule | |
|---|---|
| Diagnosis in short | |
 Sertoli cell nodule. H&E stain. | |
|
| |
| Synonyms | Pick's adenoma, testicular tubular adenoma, tubular adenoma of the testis |
|
| |
| LM | unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a tubular adenoma of the gastrointestinal tract) |
| LM DDx | Sertoli cell tumour, sex cord tumour with annular tubules, gonadoblastoma |
| IHC | alpha-inhibin +ve, PLAP -ve |
| Site | testis |
|
| |
| Clinical history | +/-undescended testis |
| Prevalence | uncommon in general |
Sertoli cell nodule, abbreviated SCN, is a benign lesion of the testis that is usually incidental.
It is also known as Pick's adenoma, testicular tubular adenoma and tubular adenoma of the testis.
General
- Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis).
- Not composed of a clonal cell population, i.e. not neoplastic; thus, technically, should not be called an adenoma.[1]
Gross
- Usually an incidental finding, rarely presents as a testicular mass.[2]
Microscopic
- Unencapsulated nodules composed of well-formed tubules.
- May contain eosinophilic (hyaline) blob in lumen (centre).
- Cells - vaguely resemble immature Sertoli cells:
- Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a tubular adenoma of the gastrointestinal tract - key feature.
DDx:[2]
Images
Sertoli cell nodule - high mag. (WC)
Sertoli cell nodule - low mag. (WC)
IHC
Features:[2]
- Alpha-inhibin +ve (5/5 cases).
- OCT3/4 -ve (5/5 cases).
Other:
- PLAP -ve.
Sign out
TESTICLE, LEFT, ORCHIECTOMY: - ATROPHIC TESTICLE WITH SERTOLI CELL NODULES. - NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA). - NEGATIVE FOR MALIGNANCY. COMMENT: The above findings are supported by immunostains. The tubules stain with alpha-inhibin and are negative for PLAP.
See also
References
- ↑ 1.0 1.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 227. ISBN 978-0470519035.
- ↑ 2.0 2.1 2.2 Vallangeon, BD.; Eble, JN.; Ulbright, TM. (Dec 2010). "Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses.". Am J Surg Pathol 34 (12): 1874-80. doi:10.1097/PAS.0b013e3181fcab70. PMID 21107095.
- ↑ Ricco R, Bufo P (October 1980). "[Histologic study of 3 cases of so-called tubular adenoma of the testis]" (in Italian). Boll. Soc. Ital. Biol. Sper. 56 (20): 2110–5. PMID 6109541.