Difference between revisions of "Cystic nephroma"
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(Michael moved page Cystic nephroma to Cystic nephroma, adult type) |
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cystic nephroma - alt -- high mag.jpg | |||
| Width = | |||
| Caption = Micrograph of cystic nephroma showing the characteristic stroma and hobnailed epithelium. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cysts lined by simple epithelium with hobnailing, stroma has an ovarian look (blue, spindle cells) | |||
| Subtypes = | |||
| LMDDx = [[mixed epithelial stromal tumour]], [[localized cystic disease of the kidney]] | |||
| Stains = | |||
| IHC = ER +ve, PR +ve, CD10 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = bubble wrap-like appearance | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other cystic kidney tumours | |||
| Tx = | |||
}} | |||
'''Cystic nephroma''' is a rare, benign [[kidney tumours|kidney tumour]]. | |||
Turbiner ''et al.''<ref name=pmid17414095>{{Cite journal | last1 = Turbiner | first1 = J. | last2 = Amin | first2 = MB. | last3 = Humphrey | first3 = PA. | last4 = Srigley | first4 = JR. | last5 = De Leval | first5 = L. | last6 = Radhakrishnan | first6 = A. | last7 = Oliva | first7 = E. | title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. | journal = Am J Surg Pathol | volume = 31 | issue = 4 | pages = 489-500 | month = Apr | year = 2007 | doi = 10.1097/PAS.0b013e31802bdd56 | PMID = 17414095 }}</ref> have suggested that ''cystic nephroma'' and ''[[mixed epithelial and stromal tumour]] (MEST)'' are one tumour; the lumping term is ''[[renal epithelial and stromal tumour]]'' (abbreviated ''REST''). | |||
==General== | |||
*Rare.<ref name=pmid20427881>{{Cite journal | last1 = Mohanty | first1 = D. | last2 = Jain | first2 = BK. | last3 = Agrawal | first3 = V. | last4 = Gupta | first4 = A. | title = Cystic nephroma: a diagnostic dilemma. | journal = Saudi J Kidney Dis Transpl | volume = 21 | issue = 3 | pages = 518-20 | month = May | year = 2010 | doi = | PMID = 20427881 }}</ref> | |||
*Good prognosis/benign.<ref name=pmid20427881/><ref name=pmid19172100/> | |||
*Considered to be on a spectrum with ''cystic partially differentiated [[nephroblastoma]]'' and ''[[Wilms tumour]].<ref name=pmid19172100>{{Cite journal | last1 = van den Hoek | first1 = J. | last2 = de Krijger | first2 = R. | last3 = van de Ven | first3 = K. | last4 = Lequin | first4 = M. | last5 = van den Heuvel-Eibrink | first5 = MM. | title = Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. | journal = Urol Int | volume = 82 | issue = 1 | pages = 65-70 | month = | year = 2009 | doi = 10.1159/000176028 | PMID = 19172100 }}</ref> | |||
==Gross== | |||
*Bubble wrap-like appearance. | |||
===Image=== | |||
<gallery> | |||
Image:Bubble_Wrap.jpg| Bubble wrap. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.sjkdt.org/viewimage.asp?img=SaudiJKidneyDisTranspl_2010_21_3_518_62699_u2.jpg Cystic nephroma (sjkdt.org)].<ref name=pmid20427881/> | |||
==Microscopic== | |||
Features: | |||
*Cysts lined by simple epithelium with hobnailing - '''key feature'''. | |||
*Stroma has an ovarian look: | |||
**''Blue'' (basophilic). | |||
**''Spindle cells''. | |||
Notes: | |||
*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts. | |||
DDx: | |||
*[[Mixed epithelial stromal tumour]]. | |||
*[[Localized cystic disease of the kidney]]. | |||
===Images=== | |||
====Case 1==== | |||
<gallery> | |||
Image:Cystic_nephroma_low_mag.jpg |Cystic nephroma - low mag. (WC/Nephron) | |||
Image:Cystic_nephroma_intermed_mag.jpg |Cystic nephroma - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
====Case 2==== | |||
<gallery> | |||
Image: Cystic nephroma -- low mag.jpg | CN - low mag. (WC/Nephron) | |||
Image: Cystic nephroma -- intermed mag.jpg | CN - intermed. mag. (WC/Nephron) | |||
Image: Cystic nephroma -- high mag.jpg | CN - high mag. (WC/Nephron) | |||
Image: Cystic nephroma - alt -- high mag.jpg | CN - high mag. (WC/Nephron) | |||
Image: Cystic nephroma -- very high mag.jpg | CN - very high mag. (WC/Nephron) | |||
Image: Cystic nephroma - a -- low mag.jpg | CN - low mag. (WC/Nephron) | |||
Image: Cystic nephroma - b -- low mag.jpg | CN - low mag. (WC/Nephron) | |||
Image: Cystic nephroma - b -- intermed mag.jpg | CN - intermed. mag. (WC/Nephron) | |||
Image: Cystic nephroma - b -- high mag.jpg | CN - high mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | |||
Features: | |||
*ER +ve. | |||
*PR +ve. | |||
*CD10 +ve. | |||
==See also== | |||
*[[Kidney tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Kidney tumours]] | |||
Revision as of 18:13, 13 March 2016
| Cystic nephroma | |
|---|---|
| Diagnosis in short | |
 Micrograph of cystic nephroma showing the characteristic stroma and hobnailed epithelium. H&E stain. | |
|
| |
| LM | cysts lined by simple epithelium with hobnailing, stroma has an ovarian look (blue, spindle cells) |
| LM DDx | mixed epithelial stromal tumour, localized cystic disease of the kidney |
| IHC | ER +ve, PR +ve, CD10 +ve |
| Gross | bubble wrap-like appearance |
| Site | kidney - see kidney tumours |
|
| |
| Prevalence | rare |
| Prognosis | benign |
| Clin. DDx | other cystic kidney tumours |
Cystic nephroma is a rare, benign kidney tumour.
Turbiner et al.[1] have suggested that cystic nephroma and mixed epithelial and stromal tumour (MEST) are one tumour; the lumping term is renal epithelial and stromal tumour (abbreviated REST).
General
- Rare.[2]
- Good prognosis/benign.[2][3]
- Considered to be on a spectrum with cystic partially differentiated nephroblastoma and Wilms tumour.[3]
Gross
- Bubble wrap-like appearance.
Image
Bubble wrap. (WC)
www:
Microscopic
Features:
- Cysts lined by simple epithelium with hobnailing - key feature.
- Stroma has an ovarian look:
- Blue (basophilic).
- Spindle cells.
Notes:
- Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.
DDx:
Images
Case 1
Cystic nephroma - low mag. (WC/Nephron)
Cystic nephroma - intermed. mag. (WC/Nephron)
Case 2
CN - low mag. (WC/Nephron)
CN - intermed. mag. (WC/Nephron)
CN - high mag. (WC/Nephron)
CN - high mag. (WC/Nephron)
CN - very high mag. (WC/Nephron)
CN - low mag. (WC/Nephron)
CN - low mag. (WC/Nephron)
CN - intermed. mag. (WC/Nephron)
CN - high mag. (WC/Nephron)
IHC
Features:
- ER +ve.
- PR +ve.
- CD10 +ve.
See also
References
- ↑ Turbiner, J.; Amin, MB.; Humphrey, PA.; Srigley, JR.; De Leval, L.; Radhakrishnan, A.; Oliva, E. (Apr 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term.". Am J Surg Pathol 31 (4): 489-500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.
- ↑ 2.0 2.1 2.2 Mohanty, D.; Jain, BK.; Agrawal, V.; Gupta, A. (May 2010). "Cystic nephroma: a diagnostic dilemma.". Saudi J Kidney Dis Transpl 21 (3): 518-20. PMID 20427881.
- ↑ 3.0 3.1 van den Hoek, J.; de Krijger, R.; van de Ven, K.; Lequin, M.; van den Heuvel-Eibrink, MM. (2009). "Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas.". Urol Int 82 (1): 65-70. doi:10.1159/000176028. PMID 19172100.