Difference between revisions of "Foamy gland carcinoma"

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#redirect [[Prostate gland#Foamy gland carcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Intraluminal eosinophilic crystalloid of prostate gland - high mag.jpg
| Width      =
| Caption    = Foamy gland carcinoma. [[H&E stain]].
| Synonyms  = foamy gland adenocarcinoma
| Micro      =
| Subtypes  = (subtype of [[prostate carcinoma]])
| LMDDx      = [[adenosis of the prostate]], [[bulbourethral gland]], [[pseudohyperplastic adenocarcinoma]]
| Stains    =
| IHC        = AMACR +ve, CK5/6 -ve, p63 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      = see ''[[prostate carcinoma]]''
| Grossing  = see ''[[prostate carcinoma]]''
| Staging    = [[prostate cancer staging]]
| Site      = [[prostate gland]] - see ''[[prostate carcinoma]]''
| Assdx      =
| Syndromes  = see ''[[prostate carcinoma]]''
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = often good, dependent on [[prostate cancer grading|grade]] & stage
| Other      =
| ClinDDx    = see ''[[prostate carcinoma]]''
| Tx        = see ''[[prostate carcinoma]]''
}}
'''Foamy gland carcinoma''', also '''foamy gland adenocarcinoma''',<ref name=pmid19033862/> is an uncommon variant of [[prostate carcinoma]] that has a bland appearance and may be confused with benign glands.


==General==
{{Main|Prostate_carcinoma#General|  l1 = Prostate carcinoma}}
*Rare.
*Usually low grade, i.e. [[Gleason score]] 6/10.<ref name=pmid19033862>{{Cite journal  | last1 = Zhao | first1 = J. | last2 = Epstein | first2 = JI. | title = High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 583-90 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818a5c6c | PMID = 19033862 }}</ref>
==Microscopic==
Features:
*Increased glandular density  - '''key feature'''.
*Eosinophilic intraluminal amorphous secretions - '''key feature'''.
*Abundant foamy cytoplasm.
*Tufted glandular border.
*Gland size larger than "typical" prostate cancer.
Note:
*Prominent [[nucleoli]] usually infrequent ''or'' absent!<ref name=pmid19033862/>
*Can be thought of as [[pseudohyperplastic adenocarcinoma]] without the nucleoli.
DDx:
*[[Adenosis of the prostate]].
*[[Bulbourethral gland]].
===Images===
<gallery>
Image: Intraluminal eosinophilic crystalloid of prostate gland - high mag.jpg | Intraluminal eosinophilic crystalloid in foamy glands. (WC)
</gallery>
www:
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f11.html#figure-title Foamy gland carcinoma (nature.com)].
==See also==
*[[Prostate carcinoma]].
==References==
{{Reflist|2}}
[[Category:Prostate carcinoma]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 03:39, 9 February 2016

Foamy gland carcinoma
Diagnosis in short

Foamy gland carcinoma. H&E stain.
Synonyms foamy gland adenocarcinoma
Subtypes (subtype of prostate carcinoma)
LM DDx adenosis of the prostate, bulbourethral gland, pseudohyperplastic adenocarcinoma
IHC AMACR +ve, CK5/6 -ve, p63 -ve
Gross see prostate carcinoma
Grossing notes see prostate carcinoma
Staging prostate cancer staging
Site prostate gland - see prostate carcinoma
Syndromes see prostate carcinoma
Prevalence uncommon
Prognosis often good, dependent on grade & stage
Clin. DDx see prostate carcinoma
Treatment see prostate carcinoma

Foamy gland carcinoma, also foamy gland adenocarcinoma,[1] is an uncommon variant of prostate carcinoma that has a bland appearance and may be confused with benign glands.

General

Main article: Prostate carcinoma

Microscopic

Features:

  • Increased glandular density - key feature.
  • Eosinophilic intraluminal amorphous secretions - key feature.
  • Abundant foamy cytoplasm.
  • Tufted glandular border.
  • Gland size larger than "typical" prostate cancer.

Note:

DDx:

Images

  • Intraluminal eosinophilic crystalloid in foamy glands. (WC)

www:

See also

References

  1. ↑ 1.0 1.1 1.2 Zhao, J.; Epstein, JI. (Apr 2009). "High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases.". Am J Surg Pathol 33 (4): 583-90. doi:10.1097/PAS.0b013e31818a5c6c. PMID 19033862.
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