Postradiation prostatic carcinoma: Difference between revisions

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'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal  | last1 = Cheng | first1 = L. | last2 = Cheville | first2 = JC. | last3 = Bostwick | first3 = DG. | title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. | journal = Am J Surg Pathol | volume = 23 | issue = 10 | pages = 1173-83 | month = Oct | year = 1999 | doi =  | PMID = 10524518 }}</ref>
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Prostatic carcinoma and radiation changes -- high mag.jpg
| Width      =
| Caption    = Prostatic carcinoma (pale glands - left/bottom of image) and radiation changes (hyperchromatic glands with nuclear atypia (upper right of image). [[H&E stain]].
| Synonyms  =
| Micro      = infiltrative growth, perineural invasion, blue mucin secretions, intraluminal crystalloids
| Subtypes  =
| LMDDx      = [[radiation changes]], [[pleomorphic tumours]], postradiation prostatic sarcoma, [[sarcomatoid prostatic carcinoma]]
| Stains    =
| IHC        = AMACR +ve, CK5/6 -ve, p63 -ve, PSA +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[prostate gland]]
| Assdx      =
| Syndromes  =
| Clinicalhx = radiation treatment, prostate carcinoma (previously diagnosed)
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  = elevated [[PSA]] or increasing PSA
| Rads      =
| Endoscopy  =
| Prognosis  = poor (?)
| Other      =
| ClinDDx    = radiation changes, infection
| Tx        = salvage prostatectomy
}}
'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is a type of [[postradiation prostate cancer]].  It is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal  | last1 = Cheng | first1 = L. | last2 = Cheville | first2 = JC. | last3 = Bostwick | first3 = DG. | title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. | journal = Am J Surg Pathol | volume = 23 | issue = 10 | pages = 1173-83 | month = Oct | year = 1999 | doi =  | PMID = 10524518 }}</ref>


==General==
==General==
*Overcall and undercall are both seen.<ref name=pmid10524518/>
*Overcall and undercall are both seen.<ref name=pmid10524518/>
*Commonly missed on core biopsies.
*Commonly missed on core biopsies.<ref name=pmid10524518/>
*History of radiation.
*History of radiation.


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Features:<ref name=pmid10524518/>
Features:<ref name=pmid10524518/>
*Infiltrative growth (diagnostic).
*Infiltrative growth (diagnostic).
*Perineural invasion (diagnostic).
*[[Perineural invasion]] (diagnostic).
*Intraluminal crystalloids.
*Intraluminal crystalloids.
*Blue mucin secretions.
*Blue mucin secretions.
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Note:
Note:
*Nuclear enlargement and nucleoli are prevalent in [[radiation changes]] of the prostate. These features are not useful in this context.<ref name=pmid10524518/>
*Nuclear enlargement and prominent [[nucleoli]] are prevalent in [[radiation changes]] of the prostate. These features are not useful in this context.<ref name=pmid10524518/>


DDx:
DDx:
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*[[Pleomorphic tumours]].
*[[Pleomorphic tumours]].
*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal  | last1 = Canfield | first1 = SE. | last2 = Gans | first2 = TH. | last3 = Unger | first3 = P. | last4 = Hall | first4 = SJ. | title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? | journal = Tech Urol | volume = 7 | issue = 4 | pages = 294-5 | month = Dec | year = 2001 | doi =  | PMID = 11763492 }}</ref>
*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal  | last1 = Canfield | first1 = SE. | last2 = Gans | first2 = TH. | last3 = Unger | first3 = P. | last4 = Hall | first4 = SJ. | title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? | journal = Tech Urol | volume = 7 | issue = 4 | pages = 294-5 | month = Dec | year = 2001 | doi =  | PMID = 11763492 }}</ref>
*[[Sarcomatoid prostatic carcinoma]].
*[[Sarcomatoid prostatic carcinoma]] - may arise following radiation.
 
===Images===
====Case====
<gallery>
Image: Prostatic carcinoma and radiation changes -- intermed mag.jpg | PC and RC - intermed. mag.
Image: Prostatic carcinoma and radiation changes - alt -- intermed mag.jpg | PC and RC - intermed. mag.
Image: Prostatic carcinoma and radiation changes -- high mag.jpg | PC and RC - high mag.
Image: Prostatic carcinoma and radiation changes -- very high mag.jpg | PC and RC - very high mag.
 
Image: Radiation changes in the prostate - alt -- high mag.jpg | RC - high mag.
Image: Radiation changes in the prostate - alt -- very high mag.jpg | RC - very high mag.
</gallery>
 
====www====
*[http://webpathology.com/image.asp?case=97&n=6 Prostate cancer with radiation changes (webpathology.com)].
*[http://webpathology.com/image.asp?case=97&n=7 Prostate cancer with radiation changes (webpathology.com)].


==IHC==
==IHC==
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*CK5/6 -ve.
*CK5/6 -ve.
*p63 -ve.
*p63 -ve.
===Images===
<gallery>
Image: Prostatic carcinoma and radiation changes - IHC -- low mag.jpg | PC and RC (AMACR-CK5/6) - low mag.
Image: Prostatic carcinoma and radiation changes - IHC -- intermed mag.jpg | PC and RC (AMACR-CK5/6) - intermed. mag.
Image: Prostatic carcinoma and radiation changes - IHC -- high mag.jpg | PC and RC (AMACR-CK5/6) - high mag.
</gallery>


==See also==
==See also==
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{{Reflist|2}}
{{Reflist|2}}


[[Category:Prostate cancer]]
[[Category:Prostate carcinoma]]
Retrieved from "https://librepathology.org/wiki/Postradiation_prostatic_carcinoma"