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Difference between revisions of "Cocaine toxicity"
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[[Image: CocaineHydrochloridePowder.jpg | thumb | 250px | Cocaine. (WC/US DEA)]] | |||
'''Cocaine toxicity''' is seen in by pathologists in the [[forensic pathology|forensic]] setting. | '''Cocaine toxicity''' is seen in by pathologists in the [[forensic pathology|forensic]] setting. | ||
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**Direct effects of norepinephrine on myocytes | **Direct effects of norepinephrine on myocytes | ||
**Vasospasm leading to myocardial ischemia. | **Vasospasm leading to myocardial ischemia. | ||
*Main metabolite (found in urine): benzoylecgonine.<ref name=pmid21664118>{{Cite journal | last1 = Munoz | first1 = EM. | last2 = Lorenzo-Abalde | first2 = S. | last3 = González-Fernández | first3 = A. | last4 = Quintela | first4 = O. | last5 = Lopez-Rivadulla | first5 = M. | last6 = Riguera | first6 = R. | title = Direct surface plasmon resonance immunosensor for in situ detection of benzoylecgonine, the major cocaine metabolite. | journal = Biosens Bioelectron | volume = 26 | issue = 11 | pages = 4423-8 | month = Jul | year = 2011 | doi = 10.1016/j.bios.2011.04.056 | PMID = 21664118 }}</ref> | |||
==Gross pathology== | ==Gross pathology== | ||
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==Microscopic== | ==Microscopic== | ||
Features (heart):<ref name=pmid1346509/> | Features (heart):<ref name=pmid1346509/> | ||
*+/-Large areas of confluent necrosis. | *+/-Large areas of confluent [[necrosis]]. | ||
*+/-Contraction band necrosis. | *+/-[[Contraction band necrosis]]. | ||
*+/-Fibrosis. | *+/-Fibrosis. | ||
*+/-Myocarditis (usu. eosinophilic). | *+/-[[Myocarditis]] (usu. eosinophilic). | ||
==See also== | ==See also== | ||