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Difference between revisions of "Osteosarcoma"
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'''Osteosarcoma''', also known as '''osteogenic sarcoma''', a malignant [[bone]] tumour. It is grouped with the [[chondro-osseous tumours]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Osteosarcoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Osteosarcoma. [[H&E stain]]. | |||
| Micro = cells with malignant features (e.g. nuclear membrane irregularities, marked nuclear size differences, mitoses) surrounded by delicate strands of osteoid | |||
| Subtypes = conventional osteosarcoma (osteoblastic osteosarcoma, [[fibroblastic osteosarcoma]], [[chondroblastic osteosarcoma]]), [[small cell osteosarcoma]], [[telangiectatic osteosarcoma]], [[parosteal osteosarcoma]], periosteal osteosarcoma, [[low-grade central osteosarcoma]], high-grade surface osteosarcoma, [[secondary osteosarcoma]], gnathic osteosarcoma | |||
| LMDDx = [[chondrosarcoma]], [[phosphaturic mesenchymal tumour, mixed connective tissue type]], [[undifferentiated pleomorphic sarcoma]] (for fibroblastic osteosarcoma), [[aneurysmal bone cyst]] (for telangiectatic osteosarcoma), [[fibrous dysplasia]], [[small round cell tumours]] (for small cell osteosarcoma) | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] | |||
| Assdx = | |||
| Syndromes = [[Li-Fraumeni syndrome]] | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[aneurysmal bone cyst]],[[fibrous dysplasia]], [[Ewing sarcoma]] | |||
}} | |||
'''Osteosarcoma''', also known as '''osteogenic sarcoma''', is a malignant [[bone]] tumour. It is grouped with the [[chondro-osseous tumours]]. | |||
==General== | ==General== | ||
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**Osteoid on H&E: pink, homogenous, "glassy". | **Osteoid on H&E: pink, homogenous, "glassy". | ||
**Tumours typically very cellular - when compared to normal bone. | **Tumours typically very cellular - when compared to normal bone. | ||
*Large (multinucleated) osteoclast-like giant cells | *+/-Large (multinucleated) osteoclast-like giant cells.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref> | ||
DDx: | |||
*[[Chondrosarcoma]]. | |||
*[[Phosphaturic mesenchymal tumour, mixed connective tissue type]]. | |||
*Others. | |||
====Images==== | ====Images==== | ||
<gallery> | <gallery> | ||
Image:Osteosarcoma - low mag.jpg|Osteosarcoma - low mag. (WC) | |||
Image:Osteosarcoma_-_intermed_mag.jpg | Osteosarcoma - intermed. mag. (WC) | Image:Osteosarcoma_-_intermed_mag.jpg | Osteosarcoma - intermed. mag. (WC) | ||
Image: Osteosarcoma - high mag.jpg|Osteosarcoma - high mag. (WC) | |||
Image:Osteosarcoma_-_very_high_mag.jpg | Osteosarcoma - very high mag. (WC) | Image:Osteosarcoma_-_very_high_mag.jpg | Osteosarcoma - very high mag. (WC) | ||
Image:Small_cell_osteosarcoma_-_intermed_mag.jpg | Small cell osteosarcoma - intermed. mag. (WC) | Image:Small_cell_osteosarcoma_-_intermed_mag.jpg | Small cell osteosarcoma - intermed. mag. (WC) | ||