Difference between revisions of "Small cell carcinoma of the lung"

From Libre Pathology
Jump to navigation Jump to search
(redirect w/ cat.)
 
(split out)
Line 1: Line 1:
#redirect [[Lung_tumours#Small_cell_carcinoma_of_the_lung]]
'''Small cell carcinoma of the lung''' is an aggressive [[malignant]] [[Lung tumours|tumour of the lung]]. It is strongly associated with [[smoking]].
 
 
==General==
*Strong association with [[smoking]].
*Typically treated with chemotherapy.
*Poor prognosis.
 
On a spectrum of lesions (benign to malignant):<ref name=pmid20943645/>
*[[lung tumourlet|Tumourlet]].
*[[typical carcinoid|Carcinoid]].
*[[atypical carcinoid|Atypical carcinoid]].
*Small cell carinoma/large cell neuroendocrine carcinoma.
 
Precursor lesion - uncommonly seen:
*Pulmonary neuroendocrine cell hyperplasia.<ref name=pmid20943645>{{Cite journal  | last1 = Travis | first1 = WD. | title = Advances in neuroendocrine lung tumors. | journal = Ann Oncol | volume = 21 Suppl 7 | issue =  | pages = vii65-71 | month = Oct | year = 2010 | doi = 10.1093/annonc/mdq380 | PMID = 20943645 }}</ref>
 
==Gross==
*Central location (close to large airways) - typical.
*[[Necrosis]].
 
==Microscopic==
Features:
*Stippled chromatin.
*High [[NC ratio]], scant basophilic cytoplasm.
*Typically small cells ~2x RBC diameter.
*+/-Nuclear moulding.
*Necrosis.
*Mitoses.
 
Notes:
*There should be no nucleolus.
 
DDx:
*Metastatic [[small cell carcinoma]].
*[[Lymphoma]].
*[[Atypical carcinoid]].
*Other [[small round blue cell tumours]].
*Large cell neuroendocrine carcinoma (LCNEC).
 
===Images===
<gallery>
Image:Lung_small_cell_carcinoma_%282%29_by_core_needle_biopsy.jpg | SCLC - low mag. (WC)
Image:Lung_small_cell_carcinoma_%281%29_by_core_needle_biopsy.jpg | SCLC - high mag. (WC)
</gallery>
==IHC==
*Synaptophysin +ve.
**May be very weak.
*TTF-1 +ve (15 of 16 cases).<ref name=pmid16138374>{{Cite journal  | last1 = Wu | first1 = M. | last2 = Szporn | first2 = AH. | last3 = Zhang | first3 = D. | last4 = Wasserman | first4 = P. | last5 = Gan | first5 = L. | last6 = Miller | first6 = L. | last7 = Burstein | first7 = DE. | title = Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers. | journal = Diagn Cytopathol | volume = 33 | issue = 4 | pages = 223-7 | month = Oct | year = 2005 | doi = 10.1002/dc.20337 | PMID = 16138374 }}</ref>
 
==Sign out==
<pre>
LOWER LOBE OF LUNG, LEFT, CORE BIOPSY:
- SMALL CELL CARCINOMA.
</pre>
 
==See also==
*[[Small cell carcinoma]].
*[[Lung tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Lung tumours]]

Revision as of 14:00, 5 January 2014

Small cell carcinoma of the lung is an aggressive malignant tumour of the lung. It is strongly associated with smoking.


General

  • Strong association with smoking.
  • Typically treated with chemotherapy.
  • Poor prognosis.

On a spectrum of lesions (benign to malignant):[1]

Precursor lesion - uncommonly seen:

  • Pulmonary neuroendocrine cell hyperplasia.[1]

Gross

  • Central location (close to large airways) - typical.
  • Necrosis.

Microscopic

Features:

  • Stippled chromatin.
  • High NC ratio, scant basophilic cytoplasm.
  • Typically small cells ~2x RBC diameter.
  • +/-Nuclear moulding.
  • Necrosis.
  • Mitoses.

Notes:

  • There should be no nucleolus.

DDx:

Images

  • SCLC - low mag. (WC)

  • SCLC - high mag. (WC)

IHC

  • Synaptophysin +ve.
    • May be very weak.
  • TTF-1 +ve (15 of 16 cases).[2]

Sign out

LOWER LOBE OF LUNG, LEFT, CORE BIOPSY:
- SMALL CELL CARCINOMA.

See also

References

  1. ↑ 1.0 1.1 Travis, WD. (Oct 2010). "Advances in neuroendocrine lung tumors.". Ann Oncol 21 Suppl 7: vii65-71. doi:10.1093/annonc/mdq380. PMID 20943645.
  2. ↑ Wu, M.; Szporn, AH.; Zhang, D.; Wasserman, P.; Gan, L.; Miller, L.; Burstein, DE. (Oct 2005). "Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers.". Diagn Cytopathol 33 (4): 223-7. doi:10.1002/dc.20337. PMID 16138374.
Retrieved from "https://librepathology.org/w/index.php?title=Small_cell_carcinoma_of_the_lung&oldid=27506"