Difference between revisions of "Sertoli cell tumour"
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| Micro = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin | | Micro = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]] | | LMDDx = [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]] | ||
| Stains = | | Stains = | ||
| IHC = alpha-inhibin, calretinin | | IHC = alpha-inhibin, calretinin | ||
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==General== | ==General== | ||
*Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | *Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | ||
*Occasionally seen in women.<ref name=pmid20349797>{{Cite journal | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Petrakopoulou | first2 = N. | last3 = Tepelenis | first3 = N. | last4 = Savvaidou | first4 = V. | last5 = Manoloudaki | first5 = K. | last6 = Katsoulis | first6 = M. | title = Pure Sertoli cell tumor. a case report and review of the literature. | journal = Eur J Gynaecol Oncol | volume = 31 | issue = 1 | pages = 117-9 | month = | year = 2010 | doi = | PMID = 20349797 }}</ref> | |||
May be seen in several syndrome - esp. if there is calcification: | May be seen in several syndrome - esp. if there is calcification: | ||
Revision as of 01:18, 26 December 2013
| Sertoli cell tumour | |
|---|---|
| Diagnosis in short | |
 Sertoli cell tumour. H&E stain. | |
|
| |
| LM | groups of cells in cords or trabeculae, cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin |
| LM DDx | granulosa cell tumour, epithelioid adenomatoid tumour, sertoli cell nodule, Sertoli-Leydig tumour |
| IHC | alpha-inhibin, calretinin |
| Site | testis, ovary |
|
| |
| Syndromes | Peutz-Jeghers syndrome, Carney complex |
|
| |
| Signs | testicular mass |
| Prevalence | uncommon |
Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis.
General
May be seen in several syndrome - esp. if there is calcification:
Microscopic
Features:
- Groups of cells in cords or trabeculae (beam-like arrangement).
- Cells have:
- Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
- Slightly irregular nucleoli.
- Granular irregular appearing chromatin.
Negatives:
- Mitoses are rare.
- No significant nuclear atypia.
DDx:
- Granulosa cell tumour - may be very similar. Often has nuclear grooves.
- Epithelioid adenomatoid tumour.
- Sertoli cell nodule.
Images
Sertoli cell tumour - high mag. (WC)
Sertoli cell tumour - low mag. (WC)
www:
IHC
- Alpha-inhibin +ve. (???)
See also
References
- ↑ Zizi-Sermpetzoglou, A.; Petrakopoulou, N.; Tepelenis, N.; Savvaidou, V.; Manoloudaki, K.; Katsoulis, M. (2010). "Pure Sertoli cell tumor. a case report and review of the literature.". Eur J Gynaecol Oncol 31 (1): 117-9. PMID 20349797.
- ↑ Libé, R.; Horvath, A.; Vezzosi, D.; Fratticci, A.; Coste, J.; Perlemoine, K.; Ragazzon, B.; Guillaud-Bataille, M. et al. (Jan 2011). "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.". J Clin Endocrinol Metab 96 (1): E208-14. doi:10.1210/jc.2010-1704. PMID 21047926.
- ↑ Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.