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Vimentin staining in a poorly differentiated carcinoma.
Vimentin staining in a lymphoma.

Vimentin is a common immunostain. It marks most soft tissue lesions and malignant melanoma. It is usually negative in carcinomas.


Vimentin and cytokeratin positivity

Common tumours:

Rare tumours:

Common tumours that uncommonly have the pattern:


See also


  1. Mısır, AF.; Durmuşlar, MC.; Zerener, T.; Gün, BD. (Apr 2016). "Primary malignant melanoma.". Saudi Med J 37 (4): 446-9. doi:10.15537/smj.2016.4.15017. PMID 27052289.
  2. Domagala, W.; Lasota, J.; Chosia, M.; Weber, K.; Osborn, M. (Feb 1989). "Leukocyte-common antigen and vimentin are reliable adjuncts in the diagnosis of non-Hodgkin's lymphoma in fine needle aspirates.". Anal Quant Cytol Histol 11 (1): 15-21. PMID 2524200.
  3. Gustmann, C.; Altmannsberger, M.; Osborn, M.; Griesser, H.; Feller, AC. (Jun 1991). "Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas.". Am J Pathol 138 (6): 1413-22. PMID 1711289.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Bahrami, A.; Truong, LD.; Ro, JY. (Mar 2008). "Undifferentiated tumor: true identity by immunohistochemistry.". Arch Pathol Lab Med 132 (3): 326-48. doi:10.1043/1543-2165(2008)132[326:UTTIBI]2.0.CO;2. PMID 18318577.
  5. Alkushi, A.; Irving, J.; Hsu, F.; Dupuis, B.; Liu, CL.; Rijn, M.; Gilks, CB. (Mar 2003). "Immunoprofile of cervical and endometrial adenocarcinomas using a tissue microarray.". Virchows Arch 442 (3): 271-7. doi:10.1007/s00428-002-0752-4. PMID 12647218.
  6. Llombart-Bosch A, Lopez-Guerrero JA, Peydro-Olaya A (2002). "Synovial sarcoma (SS): new perspectives supported by modern technology". Arkh. Patol. 64 (3): 39–47. PMID 15338724.
  7. Itakura E, Tamiya S, Morita K, et al. (September 2001). "Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor: three-dimensional imaging with confocal laser scanning microscopy and double immunofluorescence". Mod. Pathol. 14 (9): 854–61. doi:10.1038/modpathol.3880401. PMID 11557780.
  8. Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF (August 1999). "Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis". Hum. Pathol. 30 (8): 934–42. PMID 10452506.
  9. URL: Accessed on: 26 April 2011.