Transitional cell carcinoma of the ovary

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Transitional cell carcinoma of the ovary is a rare malignant ovarian tumour. It is thought to be related to high-grade serous carcinoma of the ovary.

General

  • Rare.
  • Traditionally in the transistional cell tumours category - in the surface epithelial group of ovarian tumours.[1]
  • Thought to be related to high-grade serous carcinoma.[2]

Microscopic

Features:[3]

  • Cystic spaces:
    • Small - punched-out border - very common.
    • Large.
  • Papillae, usu. large, blunt.
    • Occasionally small and filiform.
  • +/-Bizarre giant cells (35%)
  • +/-Gland-like tubules.
  • +/-Squamous differentiation.
  • +/-Psammoma bodies.
  • Cells:
    • Moderate basophilic cytoplasm and little intervening stroma.
    • Marked nuclear pleomorphism.
    • Mitoses - common.

Notes:

  1. Resembles urothelial carcinoma.[4]
  2. No Brenner tumour component (benign or malignant) should be present.[4]

Images

IHC

Features:[4]

  1. Vimentin +ve,
  2. CA-125 +ve.
  3. WT1 +ve.
  4. CK20 -ve.
  5. Thrombomodulin -ve.
  6. Uroplakin III -ve.

Notes:

  • 1-6 usu. opposite pattern in urothelial cell carcinoma.

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 401. ISBN 978-0781765275.
  2. Ali, RH.; Seidman, JD.; Luk, M.; Kalloger, S.; Gilks, CB. (Nov 2012). "Transitional cell carcinoma of the ovary is related to high-grade serous carcinoma and is distinct from malignant brenner tumor.". Int J Gynecol Pathol 31 (6): 499-506. doi:10.1097/PGP.0b013e31824d7445. PMID 23018212.
  3. Eichhorn, JH.; Young, RH. (Apr 2004). "Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis.". Am J Surg Pathol 28 (4): 453-63. PMID 15087664.
  4. 4.0 4.1 4.2 Tazi, EM.; Lalya, I.; Tazi, MF.; Ahellal, Y.; M'rabti, H.; Errihani, H. (2010). "Transitional cell carcinoma of the ovary: a rare case and review of literature.". World J Surg Oncol 8: 98. doi:10.1186/1477-7819-8-98. PMID 21073751.