Testicular metastasis

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Testicular metastasis
Diagnosis in short

Testis with metastatic prostate carcinoma. H&E stain. (WC)

Synonyms testicle with metastatic disease

LM atypical cells between seminiferous tubules, negative for GCNIS, +/-lymphovascular invasion
IHC IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, SALL4 -ve)
Site testis

Clinical history +/-history of malignancy
Signs testicular mass
Prevalence rare - esp. as first presentation
Prognosis poor
Clin. DDx primary testicular tumour

Testicular metastasis is a the discontiguous spread of a malignant tumour to the testis.


  • Rare as first presentation - case report worthy.[1][2]
  • May be the first manifestation of an abdominal malignancy.[2]


Most common in order:[2]

  • Prostate, lung, melanoma, kidney, GI tract.






See also


  1. 1.0 1.1 Li, B.; Cai, H.; Kang, ZC.; Wu, H.; Hou, JG.; Ma, LY. (Jun 2015). "Testicular metastasis from gastric carcinoma: A case report.". World J Gastroenterol 21 (21): 6764-8. doi:10.3748/wjg.v21.i21.6764. PMID 26074716.
  2. 2.0 2.1 2.2 2.3 Cormio, L.; Sanguedolce, F.; Massenio, P.; Di Fino, G.; Bruno, M.; Carrieri, G. (2015). "Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report.". J Med Case Rep 9: 139. doi:10.1186/s13256-015-0626-4. PMID 26066034.
  3. Fragkoulis, C.; Pappas, A.; Goumas, G.; Gkialas, I.; Ntoumas, K.. "Renal cell carcinoma with metastasis to the testis.". J BUON 20 (2): 663. PMID 26011366.
  4. Shinn, BJ.; Greenwald, DW.; Ahmad, N. (2015). "Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma.". BMJ Case Rep 2015. doi:10.1136/bcr-2015-209914. PMID 25994435.
  5. 5.0 5.1 Buck, DA.; Byrd, RH.; Holmes, CL.; Pollock, T.. "Testicular metastasis in a case of squamous cell carcinoma of the lung.". Case Rep Oncol 8 (1): 133-7. doi:10.1159/000380814. PMID 25873879.