TFE3

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TFE3
Immunostain in short
Use screen to detect TFE3 rearrangements
Subspeciality urologic pathology, soft tissue pathology
Normal staining pattern nuclear stain
Positive Xp11.2 translocation carcinoma, alveolar soft part sarcoma
Negative normal tissues

TFE3 is an immunostain used in uropathology and soft tissue pathology.

Negative

  • Normal tissue.[1]
    • Staining in normal tissue described as "extremely rare" - negative in adrenal gland, breast, colon, gallbaldder, lymph node, liver, prostate and skin.[2]

Positive

See also

References

  1. URL: http://www.ihcworld.com/_newsletter/2003/focus_jul_2003.pdf. Accessed on: September 11, 2017.
  2. Argani, P.; Lal, P.; Hutchinson, B.; Lui, MY.; Reuter, VE.; Ladanyi, M. (Jun 2003). "Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay.". Am J Surg Pathol 27 (6): 750-61. PMID 12766578.
  3. Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM (May 2014). "Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study". Hum. Pathol. 45 (5): 1039–44. doi:10.1016/j.humpath.2013.12.021. PMID 24746209.