Vascular tumours
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This article covers soft tissue vascular tumours. Vascular malformations are covered in the vascular malformations article.
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Normal histology
Normal blood vessel histology is dealt with in the vascular disease article.
Mimics
Distinct entities
Hemangioma
Main article: Hemangioma
Main article: Liver hemangioma
Lymphangioma
General
- Benign.
- Classically in the left neck.[1]
- May be seen in Turner syndrome.
Treatment:
- Surgical excision.
Microscopic
- Thin-walled channels lined by endothelium.
- +/-Eosinophilic intraluminal material.
- +/-Clusters of intraluminal lymphocytes.
- +/-Occasional RBCs.
DDx:
Images:
IHC
- D2-40 +ve.
Kaposi sarcoma
Main article: Kaposi sarcoma
Masson hemangioma
Main article: intravascular papillary endothelial hyperplasia
Angiosarcoma
Main article: Angiosarcoma
Kaposiform hemangioendothelioma
General
- Locally aggressive.[7]
- Childhood tumour.[8]
- Approximately half have Kasabach–Merritt phenomenon[8] = vascular tumour --> coagulopathy.
Microscopic
Features:[9]
- Spindle cells lesions in sheets or nodules.
- +/-Round tumour nodules - "cannon ball" appearance.
DDx:
IHC
Features:[9]
- Vimentin +ve.
- C31 +ve.
- CD34 +ve.
- UEA-1 lectin +ve.
Epithelioid hemangioendothelioma
Main article: Epithelioid hemangioendothelioma
Retiform hemangioendothelioma
Main article: Retiform hemangioendothelioma
Intimal sarcoma
Main article: Intimal sarcoma
See also
References
- ↑ 1.0 1.1 1.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 12. ISBN 978-0781765275.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 489. ISBN 978-0781765275.
- ↑ Kalof, AN.; Cooper, K. (Jan 2009). "D2-40 immunohistochemistry--so far!". Adv Anat Pathol 16 (1): 62-4. doi:10.1097/PAP.0b013e3181915e94. PMID 19098468.
- ↑ Kahn, HJ.; Bailey, D.; Marks, A. (Apr 2002). "Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas.". Mod Pathol 15 (4): 434-40. doi:10.1038/modpathol.3880543. PMID 11950918.
- ↑ Korkolis DP, Papaevangelou M, Koulaxouzidis G, Zirganos N, Psichogiou H, Vassilopoulos PP (2005). "Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma". Anticancer Res. 25 (2B): 1409–12. PMID 15865098.
- ↑ URL: http://path.upmc.edu/cases/case544/dx.html. Accessed on: 25 January 2012.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 603. ISBN 978-0781765275.
- ↑ 8.0 8.1 Lyons, LL.; North, PE.; Mac-Moune Lai, F.; Stoler, MH.; Folpe, AL.; Weiss, SW. (May 2004). "Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma.". Am J Surg Pathol 28 (5): 559-68. PMID 15105642.
- ↑ 9.0 9.1 9.2 Miller, K. (Mar 1991). "Sister-chromatid exchange in human B- and T-lymphocytes exposed to bleomycin, cyclophosphamide, and ethyl methanesulfonate.". Mutat Res 247 (1): 175-82. PMID 1706068. http://www.nature.com/modpathol/journal/v14/n11/full/3880441a.html.