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*[http://commons.wikimedia.org/wiki/File:VCJD_Tonsil.jpg vCJD - IHC (WC)]. | *[http://commons.wikimedia.org/wiki/File:VCJD_Tonsil.jpg vCJD - IHC (WC)]. | ||
=Lewy body diseases | =Alpha-synucleinopathies= | ||
Includes the Lewy body diseases [[Parkinson's disease]] and [[Dementia with Lewy bodies]]. | |||
==Dementia with Lewy bodies== | |||
===General=== | |||
Clinical features: | |||
Clinical features | |||
*Parkinsonian features. | *Parkinsonian features. | ||
*Hallucinations (visual). | *Hallucinations (visual). | ||
*Progressive cognitive decline with fluctuations. | *Progressive cognitive decline with fluctuations. | ||
===Microscopic=== | |||
Features: | |||
*Lewy bodies. | |||
===IHC=== | |||
*Alpha-synuclein +ve. | |||
==Parkinson disease== | ==Parkinson disease== | ||
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*Alpha-synuclein +ve. | *Alpha-synuclein +ve. | ||
==Multiple system atrophy== | ==Multiple system atrophy== | ||
===General=== | ===General=== |
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