Difference between revisions of "Neurodegenerative diseases"

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*[http://commons.wikimedia.org/wiki/File:VCJD_Tonsil.jpg vCJD - IHC (WC)].
*[http://commons.wikimedia.org/wiki/File:VCJD_Tonsil.jpg vCJD - IHC (WC)].


=Lewy body diseases=
=Alpha-synucleinopathies=
DDx:
Includes the Lewy body diseases [[Parkinson's disease]] and [[Dementia with Lewy bodies]].
*Parkinson's disease.
*Dementia with Lewy bodies.


Etiology:
==Dementia with Lewy bodies==
*Alpha-synuclein.
===General===
 
Clinical features:  
Clinical features of Dementia with Lewy bodies:  
*Parkinsonian features.
*Parkinsonian features.
*Hallucinations (visual).
*Hallucinations (visual).
*Progressive cognitive decline with fluctuations.
*Progressive cognitive decline with fluctuations.
===Microscopic===
Features:
*Lewy bodies.
===IHC===
*Alpha-synuclein +ve.


==Parkinson disease==
==Parkinson disease==
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*Alpha-synuclein +ve.
*Alpha-synuclein +ve.


=Alpha-synucleinopathies=
==Multiple system atrophy==
==Multiple system atrophy==
===General===
===General===
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