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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 20:12, 4 December 2011
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*[[Trisomy 21]] (Down syndrome) - increases risk.<ref>{{Cite journal | last1 = Nieuwenhuis-Mark | first1 = RE. | title = Diagnosing Alzheimer's dementia in Down syndrome: problems and possible solutions. | journal = Res Dev Disabil | volume = 30 | issue = 5 | pages = 827-38 | month = | year = | doi = 10.1016/j.ridd.2009.01.010 | PMID = 19269132 }} | *[[Trisomy 21]] (Down syndrome) - increases risk.<ref>{{Cite journal | last1 = Nieuwenhuis-Mark | first1 = RE. | title = Diagnosing Alzheimer's dementia in Down syndrome: problems and possible solutions. | journal = Res Dev Disabil | volume = 30 | issue = 5 | pages = 827-38 | month = | year = | doi = 10.1016/j.ridd.2009.01.010 | PMID = 19269132 }} | ||
</ref> | </ref> | ||
*Seen in conjunction with vascular amyloid deposition; see ''[[cerebral amyloid angiopathy]]''. | |||
===Gross=== | ===Gross=== | ||
Features: | Features: | ||
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#*Considered to be more specific for Alzheimer's than NF tangles. | #*Considered to be more specific for Alzheimer's than NF tangles. | ||
#*There is a staging system for plaques I (mild), II (moderate), III (severe). | #*There is a staging system for plaques I (mild), II (moderate), III (severe). | ||
#* | #*Images: [http://library.med.utah.edu/WebPath/jpeg5/CNS091.jpg Senile plaques (utah.edu)]<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/npfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/npfrm.html]. Accessed on: 5 December 2010.</ref> [http://commons.wikimedia.org/wiki/File:Cerebral_amyloid_angiopathy_-2a-_amyloid_beta_-_high_mag.jpg Senile plaques - beta-APP - high mag. (WC)]. | ||
Notes: | Notes: | ||
*Abeta amyloid: | *Abeta amyloid: | ||