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Difference between revisions of "Breast pathology"
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resort
m (→Microscopic: +key) |
(resort) |
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DDx: | DDx: | ||
*Flat epithelial atypia (>2 cell layers).{{Fact}} | *Flat epithelial atypia (>2 cell layers).{{Fact}} | ||
==Gynecomastoid hyperplasia== | ==Gynecomastoid hyperplasia== | ||
| Line 326: | Line 305: | ||
=Lesions with increased risk of malignancy= | =Lesions with increased risk of malignancy= | ||
==Sclerosing adenosis== | |||
===General=== | |||
*Can be scary... can look like [[ductal carcinoma]]. | |||
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement). | |||
**Think ''scaring'' + ''lotsa glands'' and you're pretty close. | |||
===Microscopic=== | |||
Features: | |||
*Acini are smaller than usual and there are more of them. | |||
**Acini often slit-like. | |||
*Fibrosis (scleroses) - pink on H&E surrounds the acini. | |||
**Can mimic a [[dysmoplastic reaction]]. | |||
Notes: | |||
*The acini should: | |||
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''. | |||
**Have two cell layers like well-behaved breast glands do. | |||
DDx: | |||
*Low-grade ductal carcinoma. | |||
==Flat epithelial atypia== | ==Flat epithelial atypia== | ||
===General=== | ===General=== | ||
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Notes: | Notes: | ||
*Histomorphologic appearance may mimic a desmoplastic reaction of stroma - leading to a misdiagnosis of malignancy. | *Histomorphologic appearance may mimic a desmoplastic reaction of stroma - leading to a misdiagnosis of malignancy. | ||
*"[[Hyaline]] | *"[[Hyaline]] - pink stuff on H&E - is the key."<ref>RS. May 2010.</ref> | ||
=Stromal lesions= | =Stromal lesions= | ||
This section (below) covers stromal lesions of the breast, which vary from benign to malignant. The most common is (the benign) fibroadenoma. | This section (below) covers stromal lesions of the breast, which vary from benign to malignant. The most common is (the benign) [[fibroadenoma]]. | ||
Non-breast stroma stromal lesions are covered in the ''[[soft tissue lesions]]'' article. [[Angiosarcoma]] (dealt with in the ''[[vascular tumours]]'' article) is the most common (non-breast stroma) sarcoma of the breast, and classically arises after treatment for a breast carcinoma. | Non-breast stroma stromal lesions are covered in the ''[[soft tissue lesions]]'' article. [[Angiosarcoma]] (dealt with in the ''[[vascular tumours]]'' article) is the most common (non-breast stroma) sarcoma of the breast, and classically arises after treatment for a breast carcinoma. | ||