Difference between revisions of "Breast pathology"

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10 bytes removed ,  18:11, 16 November 2011
resort
(resort)
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DDx:
DDx:
*Flat epithelial atypia (>2 cell layers).{{Fact}}
*Flat epithelial atypia (>2 cell layers).{{Fact}}
==Sclerosing adenosis==
===General===
*Can be scary... can look like [[ductal carcinoma]].
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement).
**Think ''scaring'' + ''lotsa glands'' and you're pretty close.
===Microscopic===
Features:
*Acini are smaller than usual and there are more of them.
**Acini often slit-like.
*Fibrosis (scleroses) - pink on H&E surrounds the acini.
**Can mimic a [[dysmoplastic reaction]].
Notes:
*The acini should:
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''.
**Have two cell layers like well-behaved breast glands do.
DDx:
*Low-grade ductal carcinoma.


==Gynecomastoid hyperplasia==
==Gynecomastoid hyperplasia==
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=Lesions with increased risk of malignancy=
=Lesions with increased risk of malignancy=
==Sclerosing adenosis==
===General===
*Can be scary... can look like [[ductal carcinoma]].
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement).
**Think ''scaring'' + ''lotsa glands'' and you're pretty close.
===Microscopic===
Features:
*Acini are smaller than usual and there are more of them.
**Acini often slit-like.
*Fibrosis (scleroses) - pink on H&E surrounds the acini.
**Can mimic a [[dysmoplastic reaction]].
Notes:
*The acini should:
**Be in lobular arrangements, i.e. in groups (benign appearance at low power) - '''key feature'''.
**Have two cell layers like well-behaved breast glands do.
DDx:
*Low-grade ductal carcinoma.
==Flat epithelial atypia==
==Flat epithelial atypia==
===General===
===General===
Line 369: Line 370:
Notes:
Notes:
*Histomorphologic appearance may mimic a desmoplastic reaction of stroma - leading to a misdiagnosis of malignancy.
*Histomorphologic appearance may mimic a desmoplastic reaction of stroma - leading to a misdiagnosis of malignancy.
*"[[Hyaline]] <nowiki>[pink stuff on H&E]</nowiki> is the key."<ref>RS. May 2010.</ref>
*"[[Hyaline]] - pink stuff on H&E - is the key."<ref>RS. May 2010.</ref>


=Stromal lesions=
=Stromal lesions=
This section (below) covers stromal lesions of the breast, which vary from benign to malignant.  The most common is (the benign) fibroadenoma.   
This section (below) covers stromal lesions of the breast, which vary from benign to malignant.  The most common is (the benign) [[fibroadenoma]].   


Non-breast stroma stromal lesions are covered in the ''[[soft tissue lesions]]'' article.  [[Angiosarcoma]] (dealt with in the ''[[vascular tumours]]'' article) is the most common (non-breast stroma) sarcoma of the breast, and classically arises after treatment for a breast carcinoma.
Non-breast stroma stromal lesions are covered in the ''[[soft tissue lesions]]'' article.  [[Angiosarcoma]] (dealt with in the ''[[vascular tumours]]'' article) is the most common (non-breast stroma) sarcoma of the breast, and classically arises after treatment for a breast carcinoma.
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