Difference between revisions of "Endometrial hyperplasia"

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==Simple endometrial hyperplasia with atypia==
==Simple endometrial hyperplasia with atypia==
===General===
*Uncommon.
===Microscopic===
===Microscopic===
Features:
Features:<ref name=Ref_GP236>{{Ref GP|236}}</ref>
*Irregular gland shape.
*Irregular dilated glands (with large lumens) - '''important feature'''.
**Glands described as "animal shapes".  
*Variation of gland size.
*Variation of gland size.
*No nuclear atypia.
**Uniform columnar nuclei.
*Normal gland density (gland area in plane of section/total area ~= 1/3).
*Nuclear atypia:<ref>{{Cite journal  | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref>
*Nuclear atypia:<ref>{{Cite journal  | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref>
**Loss of basal nuclear stratification - '''important'''.
**Loss of basal nuclear stratification.
**Nuclear size variation.  
**Nuclear size variation.  
**Nuclear rounding.  
**Nuclear rounding.  
***Nuclei lacking atypical = uniform columnar nuclei.
***Nuclei lacking atypical = uniform columnar nuclei.
**Nucleoli.
**Nucleoli.
**Hyperchromasia or vesicular nuclei.
Notes:
*There are no clear criteria for atypia. Different sources list different features.
*VL criteria for atypia:
*#Increased NC ratio
*#*Atypical: ~ 1:2
*#*Not atypical: ~1:3.
*#Oval nuclei with small major axis to minor axis ratio.
*#*Atypical: major axis:minor axis = <=2:1.
*#*Not atypical: major axis:minor axis = >=3:1
*#**NB: round nuclei: major axis:minor axis = 1:1.
*#Nucleoli.


==Complex endometrial hyperplasia==
==Complex endometrial hyperplasia==
48,790

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