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*Nuclear enlargement. | *Nuclear enlargement. | ||
*Mitoses common. | *Mitoses common. | ||
* | *No nuclear atypia. | ||
Notes: | Notes: | ||
*Normal ''gland-to-stroma ratio'' is 1:3. | *Normal ''gland-to-stroma ratio'' is 1:3. | ||
Image: | |||
*[http://www.webpathology.com/image.asp?n=1&Case=568 Endometrial hyperplasia (webpathology.com)]. | *[http://www.webpathology.com/image.asp?n=1&Case=568 Endometrial hyperplasia (webpathology.com)]. | ||
[[Endometrial carcinoma]] vs. complex endometrial hyperplasia: | [[Endometrial carcinoma]] vs. complex endometrial hyperplasia: | ||
*Complex endometrial hyperplasia: non-confluent (glands distinct from one another). | *Complex endometrial hyperplasia: non-confluent (glands distinct from one another). | ||
*Diagnosis of complex EH is based on histology (cytologic features). | *Diagnosis of complex EH is based on histology (cytologic features). | ||
==Complex endometrial hyperplasia with atypia== | |||
===Microscopic=== | |||
Features: | |||
*Increase in size & number of glands + irreg. shape. | |||
**Need cribriform architecture. | |||
**Two "touching" glands are likely one gland in section. | |||
*Cell stratification. | |||
*Nuclear enlargement. | |||
*Mitoses common. | |||
*Nuclear atypia present. | |||
Image: | |||
*[http://www.webpathology.com/image.asp?n=2&Case=568 Complex endometrial hyperplasia with atypia (webpathology.com)]. | |||
=See also= | =See also= |
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