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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sertoli_cell_tumour_high_mag.jpg | |||
| Width = | |||
| Caption = Sertoli cell tumour. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin | |||
| Subtypes = | |||
| LMDDx = [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]] | |||
| Stains = | |||
| IHC = [[SF-1]] +ve, alpha-inhibin +ve, calretinin +ve/-ve, | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[testis]], [[ovary]] | |||
| Assdx = | |||
| Syndromes = [[Peutz-Jeghers syndrome]], [[Carney complex]] | |||
| Clinicalhx = | |||
| Signs = testicular mass | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. It is occasionally seen in women. | |||
==General== | |||
*Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | |||
*Occasionally seen in women.<ref name=pmid20349797>{{Cite journal | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Petrakopoulou | first2 = N. | last3 = Tepelenis | first3 = N. | last4 = Savvaidou | first4 = V. | last5 = Manoloudaki | first5 = K. | last6 = Katsoulis | first6 = M. | title = Pure Sertoli cell tumor. a case report and review of the literature. | journal = Eur J Gynaecol Oncol | volume = 31 | issue = 1 | pages = 117-9 | month = | year = 2010 | doi = | PMID = 20349797 }}</ref> | |||
May be seen in several syndrome - esp. if there is calcification: | |||
*[[Carney complex]].<ref name=pmid21047926>{{Cite journal | last1 = Libé | first1 = R. | last2 = Horvath | first2 = A. | last3 = Vezzosi | first3 = D. | last4 = Fratticci | first4 = A. | last5 = Coste | first5 = J. | last6 = Perlemoine | first6 = K. | last7 = Ragazzon | first7 = B. | last8 = Guillaud-Bataille | first8 = M. | last9 = Groussin | first9 = L. | title = Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. | journal = J Clin Endocrinol Metab | volume = 96 | issue = 1 | pages = E208-14 | month = Jan | year = 2011 | doi = 10.1210/jc.2010-1704 | PMID = 21047926 }}</ref> | |||
*[[Peutz-Jeghers syndrome]].<ref name=pmid22732638>{{Cite journal | last1 = Gourgari | first1 = E. | last2 = Saloustros | first2 = E. | last3 = Stratakis | first3 = CA. | title = Large-cell calcifying Sertoli cell tumors of the testes in pediatrics. | journal = Curr Opin Pediatr | volume = 24 | issue = 4 | pages = 518-22 | month = Aug | year = 2012 | doi = 10.1097/MOP.0b013e328355a279 | PMID = 22732638 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Groups of cells in ''cords'' or ''trabeculae'' (beam-like arrangement). | |||
*Cells have: | |||
**Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles. | |||
**Slightly irregular nucleoli. | |||
**Granular irregular appearing chromatin. | |||
Negatives: | |||
*Mitoses are rare. | |||
*No significant nuclear atypia. | |||
DDx: | |||
*[[Granulosa cell tumour]] - may be very similar. Often has nuclear grooves. | |||
*Epithelioid [[adenomatoid tumour]]. | |||
*[[Sertoli cell nodule]]. | |||
*[[Sertoli-Leydig tumour]] - esp. in [[ovary]]. | |||
===Images=== | |||
<gallery> | |||
Image:Sertoli_cell_tumour_high_mag.jpg | Sertoli cell tumour - high mag. (WC) | |||
Image:Sertoli_cell_tumour_low_mag.jpg | Sertoli cell tumour - low mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case275/micro.html Sertoli cell tumour with calcification in Carney complex - several images (upmc.edu)]. | |||
==IHC== | |||
*Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>). | |||
*[[Calretinin]] +ve (~55% of cases<ref name=pmid17721194/>). | |||
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref> | |||
**Negative beta-catenin should make one consider other diagnoses.{{fact}} | |||
**May be negative in malignant sertoli cell tumours. | |||
*[[SF-1]] +ve.<ref name=pmid23165333>{{cite journal |authors=Sangoi AR, McKenney JK, Brooks JD, Higgins JP |title=Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases |journal=Appl Immunohistochem Mol Morphol |volume=21 |issue=4 |pages=318–21 |date=July 2013 |pmid=23165333 |doi=10.1097/PAI.0b013e318277cf5a |url=}}</ref> | |||
**Germ cell tumours -ve. | |||
Others: | |||
*WT-1 +ve.<ref name=pmid17721194>{{Cite journal | last1 = Zhao | first1 = C. | last2 = Bratthauer | first2 = GL. | last3 = Barner | first3 = R. | last4 = Vang | first4 = R. | title = Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1378-86 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e3180339961 | PMID = 17721194 }}</ref> | |||
==See also== | |||
*[[Leydig cell tumour]]. | |||
*[[Sertoli-Leydig tumour]]. | |||
*[[Sex cord-stromal tumours]] | |||
*[[Testis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Testis]] |
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