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Difference between revisions of "Prostate gland"
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Glands often have a jagged edges/prows (in cancer the glands tend to have round edges). | *Glands often have a jagged edges/prows (in cancer the glands tend to have round edges) - '''key feature'''. | ||
**Prow = forward most part of a ship's bow that cuts through the water.<ref>[http://en.wikipedia.org/wiki/Prow http://en.wikipedia.org/wiki/Prow]</ref> | **Prow = forward most part of a ship's bow that cuts through the water.<ref>[http://en.wikipedia.org/wiki/Prow http://en.wikipedia.org/wiki/Prow]</ref> | ||
***You may have come across ''prow'' in the context of [[breast cancer]], i.e. ''tubular carcinoma''. | ***You may have come across ''prow'' in the context of [[breast cancer]], i.e. ''tubular carcinoma''. | ||
*Gland density is usually lower than in prostate carcinoma, i.e. glands are not back-to-back - '''key feature'''. | |||
*Atrophic glands are often hyperchromatic.<ref>SN. June 3, 2009.</ref> | *Atrophic glands are often hyperchromatic.<ref>SN. June 3, 2009.</ref> | ||
*Scant cytoplasm - usually. | *Scant cytoplasm - usually. | ||
| Line 88: | Line 89: | ||
*Should have two cell layers, i.e. epithelial and myoepithelial (may be difficult to see). | *Should have two cell layers, i.e. epithelial and myoepithelial (may be difficult to see). | ||
=== | ===Atrophy vs. cancer=== | ||
Atrophy | {| class="wikitable" | ||
| | | |||
|'''Atrophy''' | |||
|'''Cancer''' | |||
|- | |||
|Glandular architecture/<br>arrangement | |||
|angulated glands, may <br>look like they originate <br>from one large duct | |||
|round glands, <br>often back-to-back | |||
|- | |||
|Nuclear <br>hyperchromasia | |||
|marked | |||
|moderate | |||
|- | |||
|Cytoplasm | |||
|scant/minimal | |||
|moderate, may <br>be amphophilic | |||
|- | |||
|Basal cells | |||
|may be visible | |||
|absent | |||
|- | |||
|Nucleoli | |||
|absent | |||
|present | |||
|- | |||
|Secretions in <br>glands | |||
|no | |||
|yes - eosinophilic <br>or blue | |||
|} | |||
==Basal cell hyperplasia== | ==Basal cell hyperplasia== | ||