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Difference between revisions of "Medical liver disease"
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===Gross=== | ===Gross=== | ||
Features:<ref>PBoD | Features:<ref>{{Ref PBoD|922}}</ref> | ||
*Well circumscribed, but no capsule. | *Well circumscribed, but no capsule. | ||
*Lighter than surrounding parenchyma, may be yellow. | *Lighter than surrounding parenchyma, may be yellow. | ||
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Note: Usually a solitary lesion.<ref name=emedicine_fnh/> | Note: Usually a solitary lesion.<ref name=emedicine_fnh/> | ||
===Histopathology=== | ===Histopathology=== | ||
Features:<ref>PBoD | Features:<ref>{{Ref PBoD|922}}</ref> | ||
*Stellate scar has large arteries with fibromuscular hyperplasia. | *Stellate scar has large arteries with fibromuscular hyperplasia. | ||
**Thin fibrous septa radiate from the central scar - surrounded by lymphocytes & bile ductules. | **Thin fibrous septa radiate from the central scar - surrounded by lymphocytes & bile ductules. | ||
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==Nodular regenerative hyperplasia== | ==Nodular regenerative hyperplasia== | ||
*Associated with renal transplants, bone marrow transplants and vasculitities.<ref>PBoD | *Associated with renal transplants, bone marrow transplants and vasculitities.<ref>{{Ref PBoD|922}}</ref> | ||
*Can lead to portal hypertension and many of the associated complications. | *Can lead to portal hypertension and many of the associated complications. | ||
===Etiology=== | ===Etiology=== | ||
*Arterial hypervascularity secondary to loss of hepatic vein radicles (loss of central venule in hepatic lobule).<ref>PBoD | *Arterial hypervascularity secondary to loss of hepatic vein radicles (loss of central venule in hepatic lobule).<ref>{{Ref PBoD|922}}</ref> | ||
ASIDE: radicle = ramulus - smallest branch or vessel or nerve.<ref>Dorlands2</ref> | ASIDE: radicle = ramulus - smallest branch or vessel or nerve.<ref>Dorlands2</ref> | ||
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===Histopathology=== | ===Histopathology=== | ||
Features:<ref>PBoD | Features:<ref>{{Ref PBoD|922}}</ref> | ||
*"Plump" hepatocytes surrounded by atrophic ones. | *"Plump" hepatocytes surrounded by atrophic ones. | ||
*No fibrosis. | *No fibrosis. | ||