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Difference between revisions of "Breast pathology"
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→Collagenous spherulosis
(→Microscopic: fix ref.) |
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==Collagenous spherulosis== | ==Collagenous spherulosis== | ||
*[[AKA]] ''mucinous spherulosis'', [[AKA]] ''spherulosis''.<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref> | |||
===General=== | ===General=== | ||
*Almost always an incidental finding. | |||
*Can mimic [[ADH]], [[DCIS]], [[adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi = | PMID = 16330938 }}</ref> | *Can mimic [[ADH]], [[DCIS]], [[adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi = | PMID = 16330938 }}</ref> | ||
**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/> | **Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/> | ||
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>URL: [http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm]. Accessed on: 31 August 2011.</ref> | Features:<ref name=stanford_collspher>URL: [http://surgpathcriteria.stanford.edu/breast/collspher/ http://surgpathcriteria.stanford.edu/breast/collspher/]. Accessed on: 4 September 2011.</ref><ref>URL: [http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm]. Accessed on: 31 August 2011.</ref> | ||
* | *Tubular/cribriform architecture. | ||
* | *Intratubular eosinophilic material - '''key feature'''. | ||
**Classical: Arranged like the spokes of a wheel ("radial spikes"). | |||
**Atypical: Granules ~ 1-2 micrometers. | |||
*No mitotic activity. | |||
*Two cells populations (epithelial & myoepithelial) - like a well-behaved breast gland. | |||
Notes: | |||
*Usually small lesions: < 50 spherules per lesion, <100 micrometers. | |||
*May be multifocal. | |||
*+/-Calcifications - may prompt biopsy. | |||
Images: | Images: | ||
*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)]. | *[[WC]]: | ||
**[http://commons.wikimedia.org/wiki/File:Collagenous_spherulosis_-_intermed_mag.jpg Collagenous spherulosis - intermed. mag. (WC)]. | |||
**[http://commons.wikimedia.org/wiki/File:Collagenous_spherulosis_-_very_high_mag.jpg Collagenous spherulosis - very high mag. (WC)]. | |||
*www: | |||
**[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)]. | |||
==Nipple adenoma== | ==Nipple adenoma== | ||