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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 04:18, 30 August 2011
, 04:18, 30 August 2011→Amyotrophic lateral sclerosis: more
(→Amyotrophic lateral sclerosis: more) |
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*[[AKA]] Lou Gehrig's disease. | *[[AKA]] Lou Gehrig's disease. | ||
*TDP-43 proteinopathy. | *TDP-43 proteinopathy. | ||
*Characterized by motor neuron death. | |||
*May be familial and associated with ''SOD1'' gene.<ref name=Ref_PCPBoD8_679>{{Ref PCPBoD8|679}}</ref> | |||
Clinical: | Clinical: | ||
*Weakness. | *Weakness. | ||
===Microscopic=== | |||
Features:<ref name=Ref_PCPBoD8_679>{{Ref PCPBoD8|679}}</ref> | |||
*Motor neurons with ''Bunina bodies''. | |||
**PAS positive cytoplasmic inclusions. | |||
*Motor neuron loss + reactive gliosis + neurogenic muscular atrophy. | |||
Images: | |||
*[http://jsp.umin.ac.jp/corepictures2007/18/o02/index.html Bunina body (umin.ac.jp)]. | |||
*[http://pathology.mc.duke.edu/neuropath/CNSlecture4/alsbunina.jpg Bunina body (duke.edu)].<ref>URL: [http://pathology.mc.duke.edu/neuropath/CNSlecture4/CNSlecture4.htm http://pathology.mc.duke.edu/neuropath/CNSlecture4/CNSlecture4.htm]. Accessed on: 30 August 2011.</ref> | |||
=See also= | =See also= | ||