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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 03:33, 30 August 2011
, 03:33, 30 August 2011→Alpha-synucleinopathies: +Pick disease
(→Prion diseases: more) |
(→Alpha-synucleinopathies: +Pick disease) |
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**Inclusions in oligodendrocytes.<ref>MUN. 16 November 2010.</ref> | **Inclusions in oligodendrocytes.<ref>MUN. 16 November 2010.</ref> | ||
=Tauopathies= | |||
==Progressive supranuclear palsy== | ==Progressive supranuclear palsy== | ||
*Commonly abbreviated ''PSP''. | *Commonly abbreviated ''PSP''. | ||
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*Grumose degeneration of the cerebellar dentate nucleus. | *Grumose degeneration of the cerebellar dentate nucleus. | ||
**Granular eosinophilic material adjacent to nuclei; once thought to be pathognomonic for PSP.<ref>URL: [http://neuropathologyblog.blogspot.com/2008/03/grumose-degeneration-in-cerebellar.html http://neuropathologyblog.blogspot.com/2008/03/grumose-degeneration-in-cerebellar.html]. Accessed on: 4 December 2010.</ref><ref>{{cite journal |author=Yamanouchi H, Yokoo H, Yuhara Y, ''et al.'' |title=An autopsy case of ornithine transcarbamylase deficiency |journal=Brain Dev. |volume=24 |issue=2 |pages=91–4 |year=2002 |month=March |pmid=11891099 |doi= |url=}}</ref> | **Granular eosinophilic material adjacent to nuclei; once thought to be pathognomonic for PSP.<ref>URL: [http://neuropathologyblog.blogspot.com/2008/03/grumose-degeneration-in-cerebellar.html http://neuropathologyblog.blogspot.com/2008/03/grumose-degeneration-in-cerebellar.html]. Accessed on: 4 December 2010.</ref><ref>{{cite journal |author=Yamanouchi H, Yokoo H, Yuhara Y, ''et al.'' |title=An autopsy case of ornithine transcarbamylase deficiency |journal=Brain Dev. |volume=24 |issue=2 |pages=91–4 |year=2002 |month=March |pmid=11891099 |doi= |url=}}</ref> | ||
==Pick disease== | |||
===General=== | |||
*Dementia. | |||
===Gross=== | |||
*Frontal and temporal lobe atrophy.<ref name=Ref_PCPBoD8_676>{{Ref PCPBoD8|676}}</ref> | |||
===Microscopic=== | |||
Features:<ref name=Ref_PCPBoD8_676>{{Ref PCPBoD8|676}}</ref> | |||
*Pick cells = large ballooned neurons. | |||
*Pick bodies = round, homogenous, intracytoplasmic inclusions, size ~10 micrometers. | |||
Image(s): | |||
*[http://www.nature.com/nrneurol/journal/v6/n2/fig_tab/nrneurol.2009.216_F1.html Pick body (nature.com)].<ref name=pmid20139998>{{Cite journal | last1 = Grossman | first1 = M. | title = Primary progressive aphasia: clinicopathological correlations. | journal = Nat Rev Neurol | volume = 6 | issue = 2 | pages = 88-97 | month = Feb | year = 2010 | doi = 10.1038/nrneurol.2009.216 | PMID = 20139998 }}</ref> | |||
=Other= | =Other= | ||